Influence of late-life exposure to environmental enrichment or exercise on hippocampal function and CA1 senescent physiology.
Influence of late-life exposure to environmental enrichment or exercise on hippocampal function and CA1 senescent physiology.
复制标题
DOI：
10.1016/j.neurobiolaging.2011.06.023
复制
发表时间：
2012-04
影响因子：
4.2
通讯作者：
Foster TC
中科院分区：
文献类型：
--
作者：
Kumar A;Rani A;Tchigranova O;Lee WH;Foster TC
将老年（20 - 22个月）雄性Fischer 344大鼠随机分配到久坐（A-SED）、环境富集（A-ENR）或运动（A-EX）条件下。经过10 - 12周的差异体验后，对三组老年大鼠和年轻的久坐对照组进行了身体和认知功能测试。在水迷宫上测试的空间辨别学习和记忆巩固，与A-SED相比，A-ENR增强。A-EX分别在线索和空间任务上表现出改善和受损的表现。A-EX大鼠的空间学习能力受损可能是由于与运动训练相关的反应选择偏差，因为A-EX大鼠的物体识别记忆得到改善。对衰老海马生理学的研究表明，丰富和运动逆转了长时程抑郁（LTD）和长时程增强（LTP）的年龄相关变化。与其他两组老年动物相比，富集组的大鼠表现出细胞兴奋性的增加。结果表明，差异的经验偏向的空间或响应策略的选择和两种条件下共同的因素，如增加与运动相关的海马活动，有助于逆转衰老的突触可塑性。
Aged (20–22 months) male Fischer 344 rats were randomly assigned to sedentary (A-SED), environmentally enriched (A-ENR) or exercise (A-EX) conditions. After 10–12 weeks of differential experience, the three groups of aged rats and young sedentary controls were tested for physical and cognitive function. Spatial discrimination learning and memory consolidation, tested on the water maze, were enhanced in A-ENR compared to A-SED. A-EX exhibited improved and impaired performance on the cue and spatial task, respectively. Impaired spatial learning in A-EX was likely due to a bias in response selection associated with exercise training, as object recognition memory improved for A-EX rats. An examination of senescent hippocampal physiology revealed that enrichment and exercise reversed age-related changes in long-term depression (LTD) and long-term potentiation (LTP). Rats in the enrichment group exhibited an increase in cell excitability compared to the other two groups of aged animals. The results indicate that differential experience biased the selection of a spatial or a response strategy and factors common across the two conditions, such as increased hippocampal activity associated with locomotion, contribute to reversal of senescent synaptic plasticity.
登录
查看更多内容
影响因子：
3.3
作者：
Driscoll, I.;Howard, S. R.;Sutherland, R. J.
通讯作者：
Sutherland, R. J.
影响因子：
2.5
作者：
Acikgoz, Osman;Aksu, Ilkay;Kayatekin, Berkant Muammer
通讯作者：
Kayatekin, Berkant Muammer
影响因子：
2.9
作者：
Cechetti, Fernanda;Fochesatto, Cintia;Siqueira, Ionara Rodrigues
通讯作者：
Siqueira, Ionara Rodrigues
影响因子：
2.7
作者：
Cracchiolo, Jennifer R.;Mori, Takashi;Arendash, Gary W.
通讯作者：
Arendash, Gary W.
影响因子：
3.4
作者：
Czurkó, A;Hirase, H;Buzsáki, G
通讯作者：
Buzsáki, G