Pulse-clamp method applied to SIROF stimulation electrodes

Pulse-clamp method applied to SIROF stimulation electrodes
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脉冲钳位法应用于 SIROF 刺激电极

DOI:
10.1016/j.snb.2009.12.015
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发表时间:
--
影响因子:
8.4
通讯作者:
U. Schnakenberg
U. Schnakenberg
中科院分区:
化学1区
文献类型:
--
作者:
A. van Ooyen;C. Ulrich;U. Schnakenberg

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小型化的电极、结构和设备对于在单神经元网络中的刺激期间实现高目标选择性是必要的,而显著的电荷转移是必不可少的。需要一种可靠的测试方法来评估用于神经刺激应用的电荷注入能力,所述神经刺激应用需要大量的电荷注入和小的电极尺寸。一个定制的脉冲钳位电路被用来表征溅射氧化铱膜(SIROF)微电极。在154mM磷酸盐缓冲盐水(PBS)溶液中,在直径小于100μm的平面微电极上进行400μs长脉冲的脉冲钳测量。单元模型被用来验证电路设计与SPICE模拟。不同尺寸的SIROF电极的脉冲箝位结果显示,即使在高电荷密度水平下,电荷损失也小于6%。
Miniaturized electrodes, structures, and devices are necessary to achieve high target selectivity during stimulation in single neuron networks, while significant charge transfer is essential. A reliable test method is required to evaluate charge injection capability for neural stimulation applications that demand both a large amount of charge injection and a small electrode size. A custom made pulse-clamp circuit was employed to characterize sputtered iridium oxide film (SIROF) microelectrodes. Pulse-clamp measurements with 400μs long pulses are performed in 154mM phosphate buffered saline (PBS) solution on planar microelectrodes smaller than 100μm in diameter. A cell model was used to verify the circuit design with SPICE simulations. The pulse-clamp results of SIROF electrodes of different sizes show charge losses of less than 6%, even at high charge density levels.
DOI: 10.1021/ac980608e
发表时间: 1998-12-01
影响因子: 7.4
作者:
Marzouk, SAM;Ufer, S;Cascio, WE
通讯作者: Cascio, WE
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发表时间: 1993
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