Myopia Alters the Structural Organization of the Retinal Vasculature, GFAP-Positive Glia, and Ganglion Cell Layer Thickness.
Myopia Alters the Structural Organization of the Retinal Vasculature, GFAP-Positive Glia, and Ganglion Cell Layer Thickness.
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近视改变视网膜血管系统、GFAP阳性胶质细胞和神经节细胞层厚度的结构组织。
DOI：
10.3390/ijms23116202
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发表时间：
2022-05-31
影响因子：
5.6
通讯作者：
Benavente-Perez, Alexandra
中科院分区：
文献类型：
--
作者：
Lin, Carol;Toychiev, Abduqodir;Ablordeppey, Reynolds;Slavi, Nefeli;Srinivas, Miduturu;Benavente-Perez, Alexandra
描述近视眼生长对星形胶质细胞、脉管系统和视网膜神经纤维层厚度的结构和分布的影响，这些对视网膜内组织的动态平衡和生存至关重要。采用免疫化学和光谱域光学相干断层扫描技术，对11只普通狨猴（Callithrix Jacchus）幼猴视网膜的星形胶质细胞和毛细血管分布、视网膜神经纤维（RNFL）和神经节细胞层（GCL）厚度进行了评估，其中6只为晶状体性近视（屈光，Rx:−7.01±1.8D）。5只未处理的年龄匹配的幼年狨猴视网膜作为对照（Rx:−0.74±0.4D）。未经治疗的狨猴眼睛生长正常，视网膜厚度增厚，星形胶质细胞数量与视网膜厚度相关。诱发性近视的狨猴没有表现出这种趋势，相反，它们的星形胶质细胞数量减少，gmap免疫阳性染色增加，RNFL变薄，外周毛细血管分支减少，弦血管数量增加。视网膜星形胶质细胞、脉管系统和视网膜神经纤维层厚度的变化提示在近视的发生和发展过程中星形胶质细胞和血管模板发生了重组。这些适应对视网膜是有益还是有害还有待研究。
To describe the effect of myopic eye growth on the structure and distribution of astrocytes, vasculature, and retinal nerve fiber layer thickness, which are critical for inner retinal tissue homeostasis and survival. Astrocyte and capillary distribution, retinal nerve fiber (RNFL), and ganglion cell layer (GCL) thicknesses were assessed using immunochemistry and spectral domain optical coherence tomography on eleven retinas of juvenile common marmosets (Callithrix Jacchus), six of which were induced with lens-induced myopia (refraction, Rx: −7.01 ± 1.8D). Five untreated age-matched juvenile marmoset retinas were used as controls (Rx: −0.74 ± 0.4D). Untreated marmoset eyes grew normally, their RNFL thickened and their astrocyte numbers were associated with RNFL thickness. Marmosets with induced myopia did not show this trend and, on the contrary, had reduced astrocyte numbers, increased GFAP-immunopositive staining, thinner RNFL, lower peripheral capillary branching, and increased numbers of string vessels. The myopic changes in retinal astrocytes, vasculature, and retinal nerve fiber layer thickness suggest a reorganization of the astrocyte and vascular templates during myopia development and progression. Whether these adaptations are beneficial or harmful to the retina remains to be investigated.
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影响因子：
5.3
作者：
Fernández-Sánchez L;Lax P;Campello L;Pinilla I;Cuenca N
通讯作者：
Cuenca N
影响因子：
4.4
作者：
Al-Sheikh, Mayss;Phasukkijwatana, Nopasak;Sarraf, David
通讯作者：
Sarraf, David
影响因子：
3
作者：
Chen M;Nofziger J;Datta R;Gee JC;Morgan J;Aguirre GK
通讯作者：
Aguirre GK
影响因子：
6.2
作者：
Dorrell, Michael I.;Aguilar, Edith;Jacobson, Ruth;Trauger, Sunia A.;Friedlander, Jeffrey;Siuzdak, Gary;Friedlander, Martin
通讯作者：
Friedlander, Martin
影响因子：
4.2
作者：
BLACK, JE;POLINSKY, M;GREENOUGH, WT
通讯作者：
GREENOUGH, WT