The Influence of Axial Length Upon the Retinal Ganglion Cell Layer of the Human Eye.
The Influence of Axial Length Upon the Retinal Ganglion Cell Layer of the Human Eye.
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DOI：
10.1167/tvst.9.13.9
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发表时间：
2020-12
影响因子：
3
通讯作者：
Aguirre GK
中科院分区：
文献类型：
--
作者：
Chen M;Nofziger J;Datta R;Gee JC;Morgan J;Aguirre GK
视网膜厚度随眼睛大小的变化使得通过光学相干断层扫描（OCT）测量来估计视网膜神经节细胞数量的努力变得复杂。我们研究了眼轴长度、神经节细胞层（GCL）的厚度和体积以及视交叉的大小之间的关系。我们使用OCT测量了50名健康参与者的GCL厚度，这些参与者具有广泛的轴向长度。使用由个体生物统计学告知的模型眼，我们将GCL厚度转换为每平方度的组织体积。我们还使用磁共振成像（MRI）测量了40名参与者的视交叉体积。GCL组织体积与眼轴长度呈正相关。鉴于先前的心理物理学结果，我们得出结论，眼轴长度增加与视网膜神经节细胞大小增加，细胞包装减少，或两者兼而有之。我们的特点是如何视网膜神经节细胞组织的体积和空间分布的轴向长度的函数系统地变化。该模型允许我们从GCL体积的个体差异测量中去除轴向长度的影响。我们发现，这种调整后的GCL体积的变化与视交叉的大小相关。我们的研究结果提供了视网膜中神经节细胞组织的体积，根据神经节细胞大小和/或包装的轴向长度的假定影响进行调整。由此产生的体积测量占视交叉的大小的个体差异，支持其用于表征后视网膜视觉通路。屈光不正的变化会混淆视网膜特征的临床测量。我们提出了一个框架内，视网膜结构的厚度和体积可以测量和校正的影响轴向长度。
Variation in retinal thickness with eye size complicates efforts to estimate retinal ganglion cell number from optical coherence tomography (OCT) measures. We examined the relationship among axial length, the thickness and volume of the ganglion cell layer (GCL), and the size of the optic chiasm. We used OCT to measure GCL thickness over 50 degrees of the horizontal meridian in 50 healthy participants with a wide range of axial lengths. Using a model eye informed by individual biometry, we converted GCL thickness to tissue volume per square degree. We also measured the volume of the optic chiasm for 40 participants using magnetic resonance imaging (MRI). There is a positive relationship between GCL tissue volume and axial length. Given prior psychophysical results, we conclude that increased axial length is associated with increased retinal ganglion cell size, decreased cell packing, or both. We characterize how retinal ganglion cell tissue varies systematically in volume and spatial distribution as a function of axial length. This model allows us to remove the effect of axial length from individual difference measures of GCL volume. We find that variation in this adjusted GCL volume correlates well with the size of the optic chiasm. Our results provide the volume of ganglion cell tissue in the retina, adjusted for the presumed effects of axial length upon ganglion cell size and/or packing. The resulting volume measure accounts for individual differences in the size of the optic chiasm, supporting its use to characterize the post-retinal visual pathway. Variations in ametropia can confound clinical measures of retinal features. We present a framework within which the thickness and volume of retinal structures can be measured and corrected for the effects of axial length.
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影响因子：
5.7
作者：
Fischl, B;Sereno, MI;Dale, AM
通讯作者：
Dale, AM
影响因子：
4.3
作者：
Benson NC;Butt OH;Brainard DH;Aguirre GK
通讯作者：
Aguirre GK
影响因子：
2.9
作者：
BLANKS, JC;HINTON, DR;MILLER, CA
通讯作者：
MILLER, CA
影响因子：
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作者：
Curcio, Christine A.;Messinger, Jeffrey D.;Spaide, Richard F.
通讯作者：
Spaide, Richard F.
影响因子：
5.7
作者：
Dale, AM;Fischl, B;Sereno, MI
通讯作者：
Sereno, MI