A meta-analysis of alcohol drinking and cancer risk.
A meta-analysis of alcohol drinking and cancer risk.
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DOI：
10.1054/bjoc.2001.2140
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发表时间：
2001-11-30
影响因子：
8.8
通讯作者：
Corrao G
中科院分区：
文献类型：
--
作者：
Bagnardi V;Blangiardo M;La Vecchia C;Corrao G
为了评估流行病学文献中关于饮酒与18种肿瘤风险之间关系的证据的强度，我们使用几个书目数据库对1966年至2000年的流行病学文献进行了检索。考虑酒精摄入的线性和非线性影响，拟合荟萃回归模型。研究特征的影响，选定的协变量（烟草）和研究中包括的个人的性别，也被调查的估计异质性的推定来源。共考虑了235项研究，包括超过117 000例病例。 观察到口腔癌、咽癌、食道癌和喉癌的风险趋势很大。胃癌、结肠癌和直肠癌、肝癌、乳腺癌和卵巢癌的直接关系不太强。对于所有这些疾病，每天摄入25克乙醇的风险也显著增加。 在胰腺癌、肺癌、前列腺癌或膀胱癌中未观察到显著或一致的相关性。允许吸烟明显地改变了与喉癌、肺癌和膀胱癌的关系，但与口腔癌、食道癌或结肠直肠癌的关系没有改变。这项荟萃分析显示，大多数酒精相关肿瘤没有阈值效应的证据。由于在几项研究中没有区分终身戒酒者和以前的饮酒者，以及可能仅在队列研究中选择性纳入相关部位，因此推断受到限制。© 2001年癌症研究运动http://www.bjcancer.com
To evaluate the strength of the evidence provided by the epidemiological literature on the association between alcohol consumption and the risk of 18 neoplasms, we performed a search of the epidemiological literature from 1966 to 2000 using several bibliographic databases. Meta-regression models were fitted considering linear and non-linear effects of alcohol intake. The effects of characteristics of the studies, of selected covariates (tobacco) and of the gender of individuals included in the studies, were also investigated as putative sources of heterogeneity of the estimates. A total of 235 studies including over 117 000 cases were considered. Strong trends in risk were observed for cancers of the oral cavity and pharynx, oesophagus and larynx. Less strong direct relations were observed for cancers of the stomach, colon and rectum, liver, breast and ovary. For all these diseases, significant increased risks were found also for ethanol intake of 25 g per day. No significant nor consistent relation was observed for cancers of the pancreas, lung, prostate or bladder. Allowance for tobacco appreciably modified the relations with laryngeal, lung and bladder cancers, but not those with oral, oesophageal or colorectal cancers. This meta-analysis showed no evidence of a threshold effect for most alcohol-related neoplasms. The inference is limited by absence of distinction between lifelong abstainers and former drinkers in several studies, and the possible selective inclusion of relevant sites only in cohort studies. © 2001 Cancer Research Campaign http://www.bjcancer.com
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影响因子：
5
作者：
GREENLAND, S;LONGNECKER, MP
通讯作者：
LONGNECKER, MP
影响因子：
6
作者：
Corrao, G;Bagnardi, V;Arico, S
通讯作者：
Arico, S
影响因子：
2.3
作者：
LONGNECKER, MP;ORZA, MJ;CHALMERS, TC
通讯作者：
CHALMERS, TC
影响因子：
2.3
作者：
LONGNECKER, MP
通讯作者：
LONGNECKER, MP
影响因子：
13.6
作者：
ARICO, S;CORRAO, G;DIORIO, F
通讯作者：
DIORIO, F