Identification of Common Neural Circuit Disruptions in Cognitive Control Across Psychiatric Disorders.
Identification of Common Neural Circuit Disruptions in Cognitive Control Across Psychiatric Disorders.
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DOI：
10.1176/appi.ajp.2017.16040400
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发表时间：
2017-07-01
期刊：
影响因子：
--
通讯作者：
Etkin A
中科院分区：
文献类型：
--
作者：
McTeague LM;Huemer J;Carreon DM;Jiang Y;Eickhoff SB;Etkin A
认知缺陷是精神障碍的常见特征。通过跨诊断神经影像荟萃分析，我们调查了精神障碍认知控制能力潜在的神经回路中断的性质。我们在PubMed上搜索了截至2015年6月发表的全脑功能神经成像文章，这些文章比较了轴心I障碍患者与匹配的健康对照组参与者在认知控制任务中的激活。被试的任务包括性能或冲突监控、反应抑制或选择、定势转移、语言流畅性、再认或工作记忆。激活似然估计的Meta分析在峰值体素坐标上进行。提交给荟萃分析的283项实验包括5728名对照组参与者和5493名患有不同障碍(精神分裂症、双相或单相抑郁、焦虑、药物使用)的患者。左侧前额叶皮质、前脑岛、右侧前额叶腹外侧区、右侧顶内沟、扣带回/辅助前运动区异常激活。在背侧扣带回皮质一个更前部的簇中也观察到了断裂，这与我们之前在灰质体积的跨诊断荟萃分析中观察到的结构扰动网络重叠。这些发现显示了一种主要精神障碍的常见干扰模式，这与在完整认知中观察到的“多重需求网络”类似。这种网络与前扣带岛或“突起网络”的接口被证明是易受灰质减少的跨诊断易损性。因此，适应性、灵活性认知所固有的网络很容易受到广谱精神病的影响。这些网络中的功能障碍可能反映了一种中间的跨诊断表型，这可能被用来促进治疗。
Cognitive deficits are a common feature of psychiatric disorders. We investigated the nature of disruptions in neural circuitry underlying cognitive control capacities across psychiatric disorders through a transdiagnostic neuroimaging meta-analysis. We searched PubMed for whole-brain functional neuroimaging articles published through June 2015 that compared activation in patients with Axis I disorders to matched healthy control participants during cognitive control tasks. Tasks that probed performance or conflict monitoring, response inhibition or selection, set shifting, verbal fluency, and recognition or working memory were included. Activation likelihood estimation meta-analyses were conducted on peak voxel coordinates. The 283 experiments submitted to meta-analysis included 5,728 control participants and 5,493 patients with different disorders (schizophrenia, bipolar or unipolar depression, anxiety, substance use). Transdiagnostically abnormal activation was evident in the left prefrontal cortex, as well as anterior insula, right ventrolateral prefrontal cortex, right intraparietal sulcus, and mid-cingulate/pre-supplementary motor area. Disruption was also observed in a more anterior cluster in the dorsal cingulate cortex, which overlapped with a network of structural perturbation we previously observed in a transdiagnostic meta-analysis of gray matter volume. These findings demonstrate a common pattern of disruption across major psychiatric disorders that parallels the “multiple demand network” observed in intact cognition. This network interfaces with the anterior-cingulo-insular or “salience network” demonstrated to be transdiagnostically vulnerable to gray matter reduction. Thus, networks intrinsic to adaptive, flexible cognition are vulnerable to broad spectrum psychopathology. Dysfunction in these networks may reflect an intermediate transdiagnostic phenotype, which could be leveraged to advance therapeutics.
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影响因子：
4.8
作者：
Eickhoff, Simon B.;Laird, Angela R.;Grefkes, Christian;Wang, Ling E.;Zilles, Karl;Fox, Peter T.
通讯作者：
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DOI：
10.1111/ejn.12764
发表时间：
2015-01
期刊：
The European journal of neuroscience
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