Resetting FLOWERING LOCUS C Expression After Vernalization Is Just Activation in the Early Embryo by a Different Name.
Resetting FLOWERING LOCUS C Expression After Vernalization Is Just Activation in the Early Embryo by a Different Name.
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DOI：
10.3389/fpls.2020.620155
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发表时间：
2020
影响因子：
5.6
通讯作者：
Helliwell CA
中科院分区：
文献类型：
--
作者：
Finnegan EJ;Robertson M;Helliwell CA
许多植物的繁殖成功取决于它们对环境做出适当反应的能力。引发开花的一个环境因素是冬季的持续寒冷，这促进了从营养生长到生殖生长的转变，这种反应被称为春化。在十字花科一年生植物中，花抑制因子 FLOWERING LOCUS C (FLC) 通过暴露在低温下而被下调。抑制在冬季寒冷时开始，然后随着温度升高而维持，使植物在春季和夏季完成其生命周期。 FLC 抑制的两个阶段（启动和维持）通过 FLC 位点的不同染色质状态来区分。起始涉及活性染色质标记的去除以及抑制标记 H3K27me3 在起始区（也称为成核区）的几个核小体上的沉积。然后，H3K27me3 以复制依赖性方式扩散覆盖整个基因座，以维持 FLC 抑制。 FLC 在下一代中从抑制中释放出来，使春化植物的后代能够应对冬季。 FLC 在这一代中的激活被称为重置，表示在春化植物的后代中恢复春化前的状态。据推测，在未经历冬季寒冷的植物的后代中，重置一定不同于FLC表达的激活。考虑到现在有强有力的证据表明染色质在雄性和雌性配子发生过程中都经历了重大修饰，是时候挑战这一假设了。
The reproductive success of many plants depends on their capacity to respond appropriately to their environment. One environmental cue that triggers flowering is the extended cold of winter, which promotes the transition from vegetative to reproductive growth in a response known as vernalization. In annual plants of the Brassicaceae, the floral repressor, FLOWERING LOCUS C (FLC), is downregulated by exposure to low temperatures. Repression is initiated during winter cold and then maintained as the temperature rises, allowing plants to complete their life cycle during spring and summer. The two stages of FLC repression, initiation and maintenance, are distinguished by different chromatin states at the FLC locus. Initiation involves the removal of active chromatin marks and the deposition of the repressive mark H3K27me3 over a few nucleosomes in the initiation zone, also known as the nucleation region. H3K27me3 then spreads to cover the entire locus, in a replication dependent manner, to maintain FLC repression. FLC is released from repression in the next generation, allowing progeny of a vernalized plant to respond to winter. Activation of FLC in this generation has been termed resetting to denote the restoration of the pre-vernalized state in the progeny of a vernalized plant. It has been assumed that resetting must differ from the activation of FLC expression in progeny of plants that have not experienced winter cold. Considering that there is now strong evidence indicating that chromatin undergoes major modifications during both male and female gametogenesis, it is time to challenge this assumption.
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影响因子：
64.8
作者：
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DOI：
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影响因子：
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DOI：
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发表时间：
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影响因子：
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