Beneficial effects of coronary venous retroinfusion but not left atrial administration of superoxide dismutase on myocardial necrosis in pigs.
Beneficial effects of coronary venous retroinfusion but not left atrial administration of superoxide dismutase on myocardial necrosis in pigs.
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冠状静脉逆向输注超氧化物歧化酶对猪心肌坏死的有益作用，但左心房注射无作用。
DOI：
10.1093/oxfordjournals.eurheartj.a059915
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发表时间：
1991
影响因子：
39.3
通讯作者：
Drury,JK
中科院分区：
文献类型：
--
作者：
Hatori,N;Tadokoro,H;Satomura,K;Miyazaki,A;Fishbein,MC;Rydén,L;Corday,E;Drury,JK
在 24 只开胸猪中研究了冠状静脉注射与左心房注射超氧化物歧化酶的功效，这些猪的左冠状动脉前降支闭塞 60 分钟，然后再灌注 3 小时。将猪随机分配到三种治疗方案：A组（n=8）在再灌注前15分钟开始将超氧化物歧化酶（5mg kg−1）注入心大静脉30分钟； B组(n=8)按与A组类似的方式向左心房灌注超氧化物歧化酶(5 mg kg−1)； C组（n=8）以与A组相同的方式将牛血清白蛋白（5 mg kg−1）注入心大静脉。A组梗死面积（以危险面积百分比表示）显着小于B组（58.7±8.3%）和C组（61.6±7.2%）（P<0.05）（28.2±13.0%）。结果表明，即使在冠状动脉侧支循环不发达的情况下，再灌注前向心大静脉回输超氧化物歧化酶可能是预防再灌注损伤的有效治疗方法。顺行（左心房）给予相同量的超氧化物歧化酶并没有减少猪的梗塞面积。对于这种功效差异的最可能的解释是，左心房给药的药物输送依赖于再灌注的顺行血流，其可靠性和效率低于冠状静脉逆行输注。后者在再灌注前的缺血期间向受损心肌提供可预测的高浓度超氧化物歧化酶。
The efficacy of coronary venous versus left atrial administration of superoxide dismutase was studied in 24 open chest pigs which had 60 min of left anterior descending coronary artery occlusion followed by 3 h reperfusion. The pigs were randomly assigned to three treatment protocols: group A (n=8) superoxide dismutase (5mg kg−1) was infused into the great cardiac vein for 30min beginning 15 min before reperfusion; group B (n=8) superoxide dismutase (5 mg kg−1) was infused into the left atrium in a similar manner to group A; group C (n=8) bovine serum albumin (5 mg kg−1) was infused into the great cardiac vein in the same manner as group A. Infarct size, expressed as percent of area at risk, was significantly smaller in group A (28.2±13.0%) than groups B (58.7 ±8.3%) and C (61.6±7.2%) (P<0.05). The results indicate that retroinfusion of superoxide dismutase into the great cardiac vein before reperfusion may be an effective treatment for the prevention of reperfusion injury, even in the absence of a well developed coronary collateral circulation. Antegrade (left atrial) administration of the same amount of superoxide dismutase did not decrease infarct size in pigs. The most likely explanation for this difference in efficacy is that drug delivery with left atrial administration is dependent on antegrade flow with reperfusion which is less reliable and less efficient than coronary venous retroinfusion. The latter provides a predictably high concentration of superoxide dismutase to the jeopardized myocardium during the period ofischaemia before reperfusion.
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DOI：
10.1093/jn/114.4.768
发表时间：
1984
期刊：
The Journal of nutrition
影响因子：
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作者：
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DOI：
10.1016/0005-2760(81)90253-8
发表时间：
1981-01-01
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
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作者：
BLANCHE, PJ;GONG, EL;NICHOLS, AV
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影响因子：
6.5
作者：
M. Huff;N. Fidge;P. Nestel;T. Billington;B. Watson
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影响因子：
7.1
作者：
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