Detecting Changes in Tissue Perfusion With Hyperspectral Imaging and Thermal Imaging Following Endovascular Treatment for Peripheral Arterial Disease.
Detecting Changes in Tissue Perfusion With Hyperspectral Imaging and Thermal Imaging Following Endovascular Treatment for Peripheral Arterial Disease.
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DOI：
10.1177/15266028221082013
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发表时间：
2023-06
影响因子：
2.6
通讯作者：
de Vries, Jean-Paul P. M.
中科院分区：
文献类型：
--
作者：
Kleiss, Simone F.;Ma, Kirsten F.;El Moumni, Mostafa;Unlu, Cagdas;Nijboer, Thomas S.;Schuurmann, Richte C. L.;Bokkers, Reinoud P. H.;de Vries, Jean-Paul P. M.
关键词：
高光谱成像（HSI）和热成像允许无接触组织灌注测量，并可能有助于确定血管内治疗（EVT）对外周动脉疾病患者的影响。本研究旨在通过HSI和围手术期热成像检测灌注的变化，并确定这些变化是否可以识别6周后临床改善的肢体。卢瑟福2-6级EVT患者纳入前瞻性研究。EVT前后直接进行高光谱成像和热成像。图像取自小腿外侧和脚底侧。记录（去）氧血红蛋白浓度、血氧饱和度和皮肤温度。血管造影结果由完成性血管造影确定。EVT后6周的临床改善定义为减少≥1个卢瑟福等级。比较有和没有良好血管造影结果或临床改善的肢体在术中灌注参数的变化。为了识别临床改善的肢体，使用受试者工作特征（ROC）曲线来确定HSI变化的临界值。纳入23例患者，29条治疗肢体。血管造影结果良好和较差的四肢之间HSI值和温度的变化无显著差异。6周随访时，经HSI测定的手术前后小腿和足部脱氧血红蛋白的变化在有和没有临床改善的肢体之间有显著差异（p=0.027和p=0.017）。小腿脱氧血红蛋白变化的ROC曲线截断值≤1.0，足部≤- 0.5，具有临床改善的判别性（敏感性77%，特异性75%，敏感性62%，特异性88%）。HSI可以检测Rutherford 2-6级患者EVT后小腿灌注的变化。手术前后小腿和足部脱氧血红蛋白的变化在有无临床改善的肢体之间有显著差异。EVT后直接脱氧血红蛋白下降可以识别EVT后6周临床改善的肢体。
Hyperspectral imaging (HSI) and thermal imaging allow contact-free tissue perfusion measurements and may help determine the effect of endovascular treatment (EVT) in patients with peripheral arterial disease. This study aimed to detect changes in perfusion with HSI and thermal imaging peri-procedurally and determine whether these changes can identify limbs that show clinical improvement after 6 weeks. Patients with Rutherford class 2–6 scheduled for EVT were included prospectively. Hyperspectral imaging and thermal imaging were performed directly before and after EVT. Images were taken from the lateral side of the calves and plantar side of the feet. Concentrations of (de)oxyhemoglobin, oxygen saturation, and skin temperature were recorded. Angiographic results were determined on completion angiogram. Clinical improvement 6 weeks after EVT was defined as a decrease ≥ one Rutherford class. Peri-procedural changes in perfusion parameters were compared between limbs with and without good angiographic results or clinical improvement. To identify limbs with clinical improvement, receiver operating characteristic (ROC) curves were used to determine cutoff values for change in HSI. Included were 23 patients with 29 treated limbs. Change in HSI values and temperature was not significantly different between limbs with good and poor angiographic results. Change in peri-procedural deoxyhemoglobin, determined by HSI, at the calves and feet was significantly different between limbs with and without clinical improvement at 6 week follow-up (p=0.027 and p=0.017, respectively). The ROC curve for change in deoxyhemoglobin at the calves showed a cutoff value of ≤1.0, and ≤−0.5 at the feet, which were discriminative for clinical improvement (sensitivity 77%; specificity 75% and sensitivity 62%; specificity 88%, respectively). HSI can detect changes in perfusion at the calves after EVT in patients with Rutherford class 2–6. Peri-procedural deoxyhemoglobin changes at the calves and feet are significantly different between limbs with and without clinical improvement. Decrease in deoxyhemoglobin directly after EVT may identify limbs that show clinical improvement 6 weeks after EVT.
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DOI：
10.1016/j.ejvs.2021.02.014
发表时间：
2021-06-14
影响因子：
5.7
作者：
Ipema, Jetty;Heinen, Stefan G. H.;van den Heuvel, Daniel A. F.
通讯作者：
van den Heuvel, Daniel A. F.
影响因子：
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作者：
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Mandrekar, Jayawant N.
影响因子：
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作者：
Grambow, Eberhard;Dau, Michael;Weinrich, Malte
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Weinrich, Malte
影响因子：
3.6
作者：
Bradbury, A. W.;Adam, D. J.;Ruckley, C. V.
通讯作者：
Ruckley, C. V.
影响因子：
168.9
作者：
Greenman, RL;Panasyuk, S;Veves, A
通讯作者：
Veves, A