Serum advanced glycation end products are associated with insulin resistance in male nondiabetic patients with obstructive sleep apnea
Serum advanced glycation end products are associated with insulin resistance in male nondiabetic patients with obstructive sleep apnea
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患有阻塞性睡眠呼吸暂停的男性非糖尿病患者血清晚期糖基化终末产物与胰岛素抵抗相关
DOI：
10.1007/s11325-014-1100-z
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发表时间：
2015-01
影响因子：
2.5
通讯作者：
Zhang Wei
中科院分区：
文献类型：
--
作者：
Xu Ji-xiong;Cai Wei;Sun Jian-fang;Liao Wei-jian;Liu Ying;Xiao Jun-ren;Zhu Ling-yan;Liu Jian-ying;Zhang Wei
目的晚期糖基化终末产物（AGEs）在糖尿病血管并发症的发病机制中起重要作用。近年来，越来越多的证据表明AGEs参与了胰岛素抵抗的发病机制。也有人认为，循环AGE与非糖尿病患者的胰岛素抵抗有关。本研究探讨血清AGEs水平是否与胰岛素抵抗的非糖尿病患者阻塞性睡眠呼吸暂停（OSA）MethodsA共139例男性非糖尿病患者参与这项研究。采用酶联免疫吸附试验检测血清AGE水平。采用稳态模型评价指数（HOMA-IR）测定胰岛素抵抗。结果血清AGEs与呼吸暂停低通气指数（AHI）呈显著相关（r= 0.281，p = 0.014），SaO 2 <90%持续时间（r= 0.267，p = 0.018）、最低SaO 2（r=-0.188，p = 0.046）、高敏C反应蛋白（hsCRP）（r= 0.274，p = 0.012）和HOMA-IR（r= 0.303，p < 0.001）。多元回归分析显示血清AGEs（p= 0.011）、AHI（p= 0.024）、腰围（p= 0.040）和hsCRP（p= 0.046）与HOMA-IR独立相关（R2= 0.392）。此外，血清AGEs和HOMA-IR之间的相关性的强度有关的严重程度OSA.ConclusionsThe本研究表明，血清AGE水平与胰岛素抵抗的男性非糖尿病患者OSA。这些结果表明，AGEs可能在OSA的胰岛素抵抗中发挥作用，也可能是OSA患者发生2型糖尿病的高风险的生物标志物。
PurposeAdvanced glycation end products (AGEs) play an important role in the pathogenesis of diabetic vascular complications. Recently, growing evidence has shown that AGEs could be involved in the pathogenesis of insulin resistance. It has also been suggested that circulating AGE are associated with insulin resistance in nondiabetic patients. This study investigated whether serum AGEs levels are associated with insulin resistance in nondiabetic patients with obstructive sleep apnea (OSA).MethodsA total of 139 male nondiabetic patients with OSA were recruited for participation in the study. Serum AGE levels were examined using an enzyme-linked immunosorbent assay. Insulin resistance was determined using the homeostasis model assessment index (HOMA-IR).ResultsThere was a significant correlation between serum AGEs and the apnea-hypopnea index (AHI) (r= 0.281,p= 0.014), duration of SaO2< 90 % (r= 0.267,p= 0.018), minimum SaO2(r= −0.188,p= 0.046), high-sensitivity C-reactive protein (hsCRP) (r= 0.274,p= 0.012), and HOMA-IR (r= 0.303,p< 0.001). Multiple regression analysis showed that serum AGEs (p= 0.011), AHI (p= 0.024), waist circumference (p= 0.040), and hsCRP (p= 0.046) were independently associated with HOMA-IR (R2= 0.392). In addition, the strength of the correlation between serum AGEs and HOMA-IR was related to the severity of OSA.ConclusionsThe present study indicated that serum AGE levels were associated with insulin resistance in male nondiabetic patients with OSA. These findings suggest that AGEs may play a role in insulin resistance in OSA and may also be a biomarker for patients with OSA with high risk of developing type 2 diabetes.
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DOI：
10.1002/dmrr.1188
发表时间：
2011-07
期刊：
Diabetes/Metabolism Research and Reviews
影响因子：
--
作者：
K. Tan;S. M. Shiu;Y. Wong;X. Tam
通讯作者：
K. Tan;S. M. Shiu;Y. Wong;X. Tam
影响因子：
4.8
作者：
Lam, Jamie C. M.;Tan, Kathryn C. B.;Ip, Mary S. M.
通讯作者：
Ip, Mary S. M.
DOI：
10.1016/s0084-3873(09)79406-4
发表时间：
2009
期刊：
Yearbook of Medicine
影响因子：
--
作者：
S. Jones
通讯作者：
S. Jones
影响因子：
7.7
作者：
Hamilton, Marc T.;Hamilton, Deborah G.;Zderic, Theodore W.
通讯作者：
Zderic, Theodore W.
DOI：
10.1073/pnas.0706446105
发表时间：
2008-01-22
影响因子：
11.1
作者：
Tasali, Esra;Leproul, Rachel;Van Cauter, Eve
通讯作者：
Van Cauter, Eve