Regional myocardial contractile function: multiparametric strain mapping.
Regional myocardial contractile function: multiparametric strain mapping.
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DOI：
10.1510/icvts.2009.220384
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发表时间：
2010-06
影响因子：
--
通讯作者：
Pasque MK
中科院分区：
文献类型：
--
作者：
Cupps BP;Taggar AK;Reynolds LM;Lawton JS;Pasque MK
具有组织标记的磁共振成像（MRI）可以量化多个应变指标，这些指标可以通过归一化组合成单一的多参数区域心肌收缩功能指标。本研究的目的是测试多参数应变分析在绵羊心肌损伤模型中量化收缩功能区域差异的能力。结扎左室前壁和心尖壁的血供可引起8只绵羊心肌收缩功能的局部变异。通过组织标记的MRI图像获得左心室收缩应变。正常应变数据库（n = 50）定义了收缩应变的所有参数，并允许通过计算z分数对15,300个左心室点的区域功能进行归一化。因此，确定了每只受伤羊左心室15,300个点的多参数收缩应变z分数。发现多参数z分数在不同地区差异显著（p < 0.001）。发现远离梗死区域的z分数明显小于最可能包括梗死心肌的区域的z分数。在这项基于mri的多参数应变分析的临床前评估中，它准确量化并直观地定义了心肌收缩功能的区域差异。
Magnetic resonance imaging (MRI) with tissue tagging enables the quantification of multiple strain indices that can be combined through normalization into a single multiparametric index of regional myocardial contractile function. The aim of this study was to test the ability of multiparametric strain analysis to quantify regional differences in contractile function in an ovine model of myocardial injury. Regional variance in myocardial contractile function was induced in eight sheep by the ligation of the blood supply to the anterior and apical left ventricular myocardial walls. Left ventricular systolic strain was obtained from tissue tagged MRI images. A normal strain database (n = 50) defines all parameters of systolic strain and allows normalization of regional function at 15,300 left ventricular points by calculation of a Z-score. Multiparametric systolic strain Z-scores were therefore determined for 15,300 points in each injured sheep left ventricle. Multiparametric Z-scores were found to vary significantly by region (p < 0.001). Z-scores in regions remote to the infarct were found to be significantly smaller than those in the regions most likely to include infarcted myocardium. In this pre-clinical evaluation of MRI-based multiparametric strain analysis, it accurately quantified and visually defined regional differences in myocardial contractile function.
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影响因子：
4.6
作者：
MARKOVITZ, LJ;SAVAGE, EB;EDMUNDS, LH
通讯作者：
EDMUNDS, LH
影响因子：
19.7
作者：
Moore, CC;Lugo-Olivieri, CH;Zerhouni, EA
通讯作者：
Zerhouni, EA
影响因子：
19.7
作者：
AXEL, L;DOUGHERTY, L
通讯作者：
DOUGHERTY, L
影响因子：
37.8
作者：
Garot, J;Bluemke, DA;Lima, JAC
通讯作者：
Lima, JAC
DOI：
10.1016/s0735-1097(02)02121-6
发表时间：
2002-09-18
影响因子：
24
作者：
Jackson, BM;Gorman, JH;Gorman, RC
通讯作者：
Gorman, RC