Smart Nanoparticles for Chemo-Based Combinational Therapy.
Smart Nanoparticles for Chemo-Based Combinational Therapy.
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DOI：
10.3390/pharmaceutics13060853
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发表时间：
2021-06-08
期刊：
影响因子：
5.4
通讯作者：
Tang L
中科院分区：
文献类型：
--
作者：
Shrestha B;Wang L;Brey EM;Uribe GR;Tang L
癌症是一种异质性复杂的疾病。传统的癌症治疗方法存在治疗指数低、获得性耐药和各种不良反应的问题。随着对癌症生物学认识的加深和技术的进步，越来越多的策略被用来优化治疗效果。纳米医学的快速发展和应用推动了这一进步。例如，联合治疗方案已经成为有效治疗癌症不可或缺的方法，包括化疗药物、化疗能量、化疗基因、化疗小分子和化疗免疫的联合治疗。此外，智能纳米平台响应外部刺激（如光、温度、超声和磁场）和/或内部刺激（如pH值、酶、缺氧和氧化还原的变化）已经被广泛研究，以提高精确治疗。用于联合治疗的智能纳米平台已经显示出成为下一代癌症治疗方案的潜力。本文综述了智能联合治疗的最新进展。
Cancer is a heterogeneous and complex disease. Traditional cancer therapy is associated with low therapeutic index, acquired resistance, and various adverse effects. With the increasing understanding of cancer biology and technology advancements, more strategies have been exploited to optimize the therapeutic outcomes. The rapid development and application of nanomedicine have motivated this progress. Combinational regimen, for instance, has become an indispensable approach for effective cancer treatment, including the combination of chemotherapeutic agents, chemo-energy, chemo-gene, chemo-small molecules, and chemo-immunology. Additionally, smart nanoplatforms that respond to external stimuli (such as light, temperature, ultrasound, and magnetic field), and/or to internal stimuli (such as changes in pH, enzymes, hypoxia, and redox) have been extensively investigated to improve precision therapy. Smart nanoplatforms for combinational therapy have demonstrated the potential to be the next generation cancer treatment regimen. This review aims to highlight the recent advances in smart combinational therapy.
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PD-1和PD-L1检查点信号传导抑制癌症免疫疗法：机制，组合和临床结果。
影响因子：
5.6
作者：
Alsaab HO;Sau S;Alzhrani R;Tatiparti K;Bhise K;Kashaw SK;Iyer AK
通讯作者：
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影响因子：
29.4
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通讯作者：
Das, Dibakar
DOI：
10.1016/j.msec.2017.03.038
发表时间：
2017-07-01
影响因子：
7.9
作者：
Amoli-Diva, Mitra;Sadighi-Bonabi, Rasoul;Pourghazi, Kamyar
通讯作者：
Pourghazi, Kamyar
纳米颗粒酶通过过氧化氢的产生和光解增强光疗
影响因子：
10.8
作者：
Chang, Kaiwen;Liu, Zhihe;Wu, Changfeng
通讯作者：
Wu, Changfeng