Neonatal intestinal dysbiosis.

Neonatal intestinal dysbiosis.
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DOI:
10.1038/s41372-020-00829-2
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发表时间:
2020-11
期刊:
Journal of perinatology : official journal of the California Perinatal Association
影响因子:
--
通讯作者:
Bevins CL
Bevins CL
中科院分区:
其他
文献类型:
--
作者:
Underwood MA;Mukhopadhyay S;Lakshminrusimha S;Bevins CL

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新生儿肠道的初始定植受分娩方式、喂养、母体微生物群和许多环境因素的影响。出生后,婴儿的微生物群的组成经历了一系列显著的变化,特别是在生命的最初几周和几个月,最终在儿童时期发展成为一个更稳定和多样化的成人样群体。肠道生态失调是与疾病相关的肠道微生物群的改变,似乎在新生儿中很常见。肠道微生态失调的后果尚不确定,但强有力的间接证据和有限的因果关系证实表明,生命早期的微生态失调会严重影响婴儿的健康,并导致生命后期的疾病易感性。
The initial colonization of the neonatal intestinal tract is influenced by delivery mode, feeding, the maternal microbiota, and a host of environmental factors. After birth, the composition of the infant’s microbiota undergoes a series of significant changes particularly in the first weeks and months of life ultimately developing into a more stable and diverse adult-like population in childhood. Intestinal dysbiosis is an alteration in the intestinal microbiota associated with disease and appears to be common in neonates. The consequences of intestinal dysbiosis are uncertain, but strong circumstantial evidence and limited confirmations of causality suggest that dysbiosis early in life can influence the health of the infant acutely, as well as contribute to disease susceptibility later in life.
细菌定植会重新编程新生儿肠道代谢组。
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