circRNADb: A comprehensive database for human circular RNAs with protein-coding annotations.
circRNADb: A comprehensive database for human circular RNAs with protein-coding annotations.
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circRNADb：具有蛋白质编码注释的人类环状 RNA 综合数据库
DOI：
10.1038/srep34985
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发表时间：
2016-10-11
影响因子：
4.6
通讯作者：
Li Y
中科院分区：
文献类型：
--
作者：
Chen X;Han P;Zhou T;Guo X;Song X;Li Y
已知环状RNA在人体组织和细胞中广泛表达，在生理或病理过程中起重要的调节作用。然而，缺乏全面注释的人类环状RNA数据库。在这项研究中，我们建立了一个circRNA数据库，命名为circRNADb，包含32，914个人类外显子circRNA精心挑选来自不同的来源。circRNA的详细信息，包括基因组信息、外显子剪接、基因组序列、内部核糖体进入位点（IRES）、开放阅读框架（ORF）和参考文献，见circRNADb。此外，发现circRNA能够编码蛋白质，这在任何物种中都没有报道。16328个circRNA被注释为具有长于100个氨基酸的ORF，其中7170个具有IRES元件。质谱分析结果显示，来自37个基因的46个circRNA有相应的蛋白质表达。该数据库提供了数据检索、浏览、下载、提交和反馈等功能，供用户研究特定的环状RNA，并不断更新数据库。circRNADb将成为未来circRNA分子及其相关生物学功能的生物信息平台。该数据库可通过网站服务器http://reprod.njmu.edu.cn/circrnadb免费提供。
It has been known that circular RNAs are widely expressed in human tissues and cells, and play important regulatory roles in physiological or pathological processes. However, there is lack of comprehensively annotated human circular RNAs database. In this study we established a circRNA database, named as circRNADb, containing 32,914 human exonic circRNAs carefully selected from diversified sources. The detailed information of the circRNA, including genomic information, exon splicing, genome sequence, internal ribosome entry site (IRES), open reading frame (ORF) and references were provided in circRNADb. In addition, circRNAs were found to be able to encode proteins, which have not been reported in any species. 16328 circRNAs were annotated to have ORF longer than 100 amino acids, of which 7170 have IRES elements. 46 circRNAs from 37 genes were found to have their corresponding proteins expressed according mass spectrometry. The database provides the function of data search, browse, download, submit and feedback for the user to study particular circular RNA of interest and update the database continually. circRNADb will be built to be a biological information platform for circRNA molecules and related biological functions in the future. The database can be freely available through the web server at http://reprod.njmu.edu.cn/circrnadb.
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通讯作者：
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14.9
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