Toll-Like Receptors, Associated Biological Roles, and Signaling Networks in Non-Mammals.
Toll-Like Receptors, Associated Biological Roles, and Signaling Networks in Non-Mammals.
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DOI：
10.3389/fimmu.2018.01523
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发表时间：
2018
影响因子：
7.3
通讯作者：
Chen J
中科院分区：
文献类型：
--
作者：
Nie L;Cai SY;Shao JZ;Chen J
先天免疫系统是对抗病原体的第一道防线，它是由模式识别受体（PRR）识别病原体相关分子模式（PAMP）和内源性损伤相关分子模式（DAMP）而启动的。在所有已识别的 PRR 中，Toll 样受体 (TLR) 是最古老的一类，具有最广泛的病原体识别谱。自从在果蝇中首次发现 Toll 以来，已在多种无脊椎动物和脊椎动物物种中鉴定出大量 TLR。 TLR、它们启动的信号通路或相关衔接蛋白似乎在从多孔动物到哺乳动物的多种生物体中本质上是保守的。分子结构分析表明，大多数 TLR 同源物具有相似的结构域模式，并且 TLR 信号传导的一些重要参与者与 TLR 本身共同进化。然而，在进化过程中确实发生了功能规范和新信号通路以及适配器的出现。此外，关于 TLR 网络的知识仍然存在模糊性和差距，特别是在低等生物中。因此，需要从比较角度对这一巨大的信号系统和整个动物界的进化模式进行系统回顾。在当前的综述中，我们概述了非哺乳动物中 TLR 的概述和可能的进化模式，希望这能为该领域的进一步研究提供线索。
The innate immune system is the first line of defense against pathogens, which is initiated by the recognition of pathogen-associated molecular patterns (PAMPs) and endogenous damage-associated molecular patterns (DAMPs) by pattern recognition receptors (PRRs). Among all the PRRs identified, the toll-like receptors (TLRs) are the most ancient class, with the most extensive spectrum of pathogen recognition. Since the first discovery of Toll in Drosophila melanogaster, numerous TLRs have been identified across a wide range of invertebrate and vertebrate species. It seems that TLRs, the signaling pathways that they initiate, or related adaptor proteins are essentially conserved in a wide variety of organisms, from Porifera to mammals. Molecular structure analysis indicates that most TLR homologs share similar domain patterns and that some vital participants of TLR signaling co-evolved with TLRs themselves. However, functional specification and emergence of new signaling pathways, as well as adaptors, did occur during evolution. In addition, ambiguities and gaps in knowledge still exist regarding the TLR network, especially in lower organisms. Hence, a systematic review from the comparative angle regarding this tremendous signaling system and the scenario of evolutionary pattern across Animalia is needed. In the current review, we present overview and possible evolutionary patterns of TLRs in non-mammals, hoping that this will provide clues for further investigations in this field.
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影响因子：
16.6
作者：
Adema CM;Hillier LW;Jones CS;Loker ES;Knight M;Minx P;Oliveira G;Raghavan N;Shedlock A;do Amaral LR;Arican-Goktas HD;Assis JG;Baba EH;Baron OL;Bayne CJ;Bickham-Wright U;Biggar KK;Blouin M;Bonning BC;Botka C;Bridger JM;Buckley KM;Buddenborg SK;Lima Caldeira R;Carleton J;Carvalho OS;Castillo MG;Chalmers IW;Christensens M;Clifton S;Cosseau C;Coustau C;Cripps RM;Cuesta-Astroz Y;Cummins SF;di Stephano L;Dinguirard N;Duval D;Emrich S;Feschotte C;Feyereisen R;FitzGerald P;Fronick C;Fulton L;Galinier R;Gava SG;Geusz M;Geyer KK;Giraldo-Calderón GI;de Souza Gomes M;Gordy MA;Gourbal B;Grunau C;Hanington PC;Hoffmann KF;Hughes D;Humphries J;Jackson DJ;Jannotti-Passos LK;de Jesus Jeremias W;Jobling S;Kamel B;Kapusta A;Kaur S;Koene JM;Kohn AB;Lawson D;Lawton SP;Liang D;Limpanont Y;Liu S;Lockyer AE;Lovato TL;Ludolf F;Magrini V;McManus DP;Medina M;Misra M;Mitta G;Mkoji GM;Montague MJ;Montelongo C;Moroz LL;Munoz-Torres MC;Niazi U;Noble LR;Oliveira FS;Pais FS;Papenfuss AT;Peace R;Pena JJ;Pila EA;Quelais T;Raney BJ;Rast JP;Rollinson D;Rosse IC;Rotgans B;Routledge EJ;Ryan KM;Scholte LLS;Storey KB;Swain M;Tennessen JA;Tomlinson C;Trujillo DL;Volpi EV;Walker AJ;Wang T;Wannaporn I;Warren WC;Wu XJ;Yoshino TP;Yusuf M;Zhang SM;Zhao M;Wilson RK
通讯作者：
Wilson RK
影响因子：
2.6
作者：
Armstrong, NJ;Steinbeisser, H;Rupp, RAW
通讯作者：
Rupp, RAW
DOI：
10.1073/pnas.1711530114
发表时间：
2017-11-21
影响因子：
11.1
作者：
Brennan, Joseph J.;Messerschmidt, Jonathan L.;Gilmore, Thomas D.
通讯作者：
Gilmore, Thomas D.
影响因子：
4.7
作者：
Arts, Joop A. J.;Cornelissen, Ferry H. J.;Stet, Rene J. M.
通讯作者：
Stet, Rene J. M.
DOI：
10.1016/j.cub.2015.07.037
发表时间：
2015-08-31
期刊：
Current biology : CB
影响因子：
--
作者：
Brandt JP;Ringstad N
通讯作者：
Ringstad N