Microglial CD206 Gene Has Potential as a State Marker of Bipolar Disorder.
Microglial CD206 Gene Has Potential as a State Marker of Bipolar Disorder.
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DOI：
10.3389/fimmu.2016.00676
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发表时间：
2016
影响因子：
7.3
通讯作者：
Kanba S
中科院分区：
文献类型：
--
作者：
Ohgidani M;Kato TA;Haraguchi Y;Matsushima T;Mizoguchi Y;Murakawa-Hirachi T;Sagata N;Monji A;Kanba S
双相情感障碍的病理生理学，特别是躁狂和抑郁状态之间的双相性的潜在机制，还有待澄清。小胶质细胞是大脑中的免疫细胞，在大脑炎症过程中起着重要作用，最近的正电子发射断层扫描研究表明双相情感障碍患者大脑中的小胶质细胞过度激活。我们最近开发了一种从外周血（单核细胞）诱导小胶质细胞样（iMG）细胞的技术。我们介绍了一种新的翻译方法，专注于双相情感障碍，使用这种iMG技术。我们假设小胶质细胞的免疫条件性变化可能有助于躁狂和抑郁状态之间的转变，因此我们在此分析了三名快速循环双相情感障碍患者在躁狂和抑郁状态下iMG细胞的基因谱模式。我们发现，基因图谱模式是不同的躁狂和抑郁状态。病例1的分析模式显示，与抑郁状态相比，M1小胶质细胞在躁狂状态中占主导地位。然而，病例2和3的模式与病例1的模式不一致。CD 206是一种甘露糖受体，被认为是典型的M2标记物，在所有三名患者的躁狂状态中显著下调。这是第一份报告，以表明转移小胶质细胞M1/M2特性的重要性，特别是抑郁和躁狂状态之间的CD 206基因表达模式。小胶质细胞在双相情感障碍的生物学机制中的作用有待进一步的研究。
The pathophysiology of bipolar disorder, especially the underlying mechanisms of the bipolarity between manic and depressive states, has yet to be clarified. Microglia, immune cells in the brain, play important roles in the process of brain inflammation, and recent positron emission tomography studies have indicated microglial overactivation in the brain of patients with bipolar disorder. We have recently developed a technique to induced microglia-like (iMG) cells from peripheral blood (monocytes). We introduce a novel translational approach focusing on bipolar disorder using this iMG technique. We hypothesize that immunological conditional changes in microglia may contribute to the shift between manic and depressive states, and thus we herein analyzed gene profiling patterns of iMG cells from three patients with rapid cycling bipolar disorder during both manic and depressive states, respectively. We revealed that the gene profiling patterns are different between manic and depressive states. The profiling pattern of case 1 showed that M1 microglia is dominant in the manic state compared to the depressive state. However, the patterns of cases 2 and 3 were not consistent with the pattern of case 1. CD206, a mannose receptor known as a typical M2 marker, was significantly downregulated in the manic state among all three patients. This is the first report to indicate the importance of shifting microglial M1/M2 characteristics, especially the CD206 gene expression pattern between depressive and manic states. Further translational studies are needed to dig up the microglial roles in the underlying biological mechanisms of bipolar disorder.
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影响因子：
6.2
作者：
Durafourt, Bryce A.;Moore, Craig S.;Antel, Jack P.
通讯作者：
Antel, Jack P.
影响因子：
25
作者：
Miron, Veronique E.;Boyd, Amanda;Zhao, Jing-Wei;Yuen, Tracy J.;Ruckh, Julia M.;Shadrach, Jennifer L.;van Wijngaarden, Peter;Wagers, Amy J.;Williams, Anna;Franklin, Robin J. M.;Ffrench-Constant, Charles
通讯作者：
Ffrench-Constant, Charles
影响因子：
3.5
作者：
Kato TA;Hayakawa K;Monji A;Kanba S
通讯作者：
Kanba S
影响因子：
15.1
作者：
Haarman, Bartholomeus C. M. ('Benno');Burger, Huibert;Riemersma-Van der Lek, Rixt F.
通讯作者：
Riemersma-Van der Lek, Rixt F.
影响因子：
8.3
作者：
Hu, Xiaoming;Li, Peiying;Chen, Jun
通讯作者：
Chen, Jun