Kinetics of interfacial radical polymerization initiated by a glucose-oxidase mediated redox system.
Kinetics of interfacial radical polymerization initiated by a glucose-oxidase mediated redox system.
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DOI：
10.1016/j.biomaterials.2012.06.014
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发表时间：
2012-10
期刊：
影响因子：
14
通讯作者：
Bowman, Christopher N.
中科院分区：
文献类型：
--
作者：
Shenoy, Raveesh;Bowman, Christopher N.
阐述了葡萄糖氧化酶引发界面聚合的反应动力学和包覆动力学。界面膜随时间快速线性生长，在不到4分钟的时间内产生高达1毫米的时间依赖性可控保形涂层厚度。只有当浸泡介质被搅拌以诱导更高的传质速率时，才观察到本体聚合。在水凝胶中的葡萄糖和本体介质中的铁的不同浓度之间观察到的显著不同的膜厚度被证明是初始快速生长阶段的结果，随后膜以几乎独立于葡萄糖或铁浓度的相同速率生长。在该初始阶段中的聚合速率和因此厚度增长速率分别在高于0.8M和0.63mM的葡萄糖和铁浓度下饱和。在铁浓度高于0.05 mM时，在3小时的反应结束时的膜厚度随着铁浓度从5.7 mm增加到4.2 mm而单调下降。葡萄糖氧化酶被捕获的增长聚合前沿，并可用作唯一的酶前体，以涂覆第二聚合物层。然而，第二层的膜生长速率比在第二阶段包衣过程中存在大量酶时的膜生长速率低14倍。
The reaction and coating kinetics for the glucose oxidase initiated interfacial polymerization are elaborated. The interfacial film grows rapidly and linearly with time, producing time-dependent controllable conformal coating thicknesses of up to a millimeter in less than 4 minutes. Bulk polymerization was only observed when the immersing media was stirred to induce higher mass transport rates. The dramatically different film thicknesses observed between different concentrations of glucose in the hydrogel and iron in the bulk media are demonstrated to be a result of an initial rapid growth phase following which the film grows at the same rate nearly independent of either the glucose or iron concentration. The polymerization rate and hence the thickness growth rate in this initial phase saturate at glucose and iron concentrations above 0.8 M and 0.63 mM, respectively. At iron concentrations above 0.05 mM, the film thickness at the end of 3 hours of reaction monotonically decreased with increasing iron concentration from 5.7 mm to 4.2 mm. The glucose oxidase is trapped by the growing polymerization front and can be used as the sole enzymatic precursor to coat a second polymeric layer. However, the rate of film growth of the second layer is 14-fold lower than the rate of film growth when bulk enzyme is present during the second stage coating process.
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影响因子：
41.2
作者：
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通讯作者：
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影响因子：
14
作者：
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影响因子：
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作者：
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通讯作者：
Bowman, Christopher N.
影响因子：
9.5
作者：
Johnson, Leah M.;DeForest, Cole A.;Pendurti, Aishwarya;Anseth, Kristi S.;Bowman, Christopher N.
通讯作者：
Bowman, Christopher N.