Effects of Norepinephrine on the Intestinal Vascular System in Rabbits With Endotoxic Shock
Effects of Norepinephrine on the Intestinal Vascular System in Rabbits With Endotoxic Shock
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去甲肾上腺素对内毒素休克家兔肠血管系统的影响
DOI：
10.1097/shk.0000000000001663
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发表时间：
2021
期刊：
影响因子：
3.1
通讯作者：
Kuwagata Yasuyuki
中科院分区：
文献类型：
--
作者：
Nakamura Fumiko;Muroya Takashi;Onoe Atsunori;Ikegawa Hitoshi;Kuwagata Yasuyuki
我们假设在内毒素休克时给予去甲肾上腺素(NE)后，空肠粘膜组织血流量会减少。本研究旨在探讨去甲肾上腺素对内毒素休克兔肠系膜上静脉(SMV)和空肠组织血流量的影响。随机分为4组，每组8只：对照组、内毒素1 mg/kg组、去甲肾上腺素(2μg/kg/min)组、内毒素+去甲肾上腺素组。以平均动脉压(MAP)、心输出量、SMV血流量和空肠粘膜组织血流量作为循环指标，从0-240分钟每隔30分钟测量一次。内毒素组的MAP下降可被NE抑制。注射脂多糖后，SMV血流量暂时下降，但随后回升。内毒素组给予NE可抑制SMV血流量的一过性下降，但不低于对照组。在内毒素组，空肠组织血流量先下降后上升，反映了SMV的血流模式。而在内毒素+去甲肾上腺素组，尽管SMV血流量没有下降，但空肠粘膜组织血流量仍然很低。在90~180min的空肠组织血流量中，NE与内毒素之间存在交互作用(P=0.033)。结果表明，去甲肾上腺素维持MAP和SMV血流量，但减少空肠组织血流量。在兔内毒素休克模型上，去甲肾上腺素对空肠组织血流量有负性影响。
We hypothesized that jejunal mucosal tissue blood flow would decrease following norepinephrine (NE) administration in endotoxic shock. We aimed of this study to evaluate changes in superior mesenteric venous (SMV) blood flow and jejunal mucosal tissue blood flow of the intestinal vascular system over time by administration of NE in rabbits with endotoxic shock. We created four groups (n= 8 each): control group, lipopolysaccharide (LPS; 1 mg/kg) group, NE (2 μg/kg/min) group, and LPS+ NE group. As indicators of circulation, we measured mean arterial blood pressure (MAP), cardiac output, SMV blood flow, and jejunal mucosal tissue blood flow every 30 min from 0 to 240 min. The drop in MAP observed in the LPS group was suppressed by NE administration. SMV blood flow dropped temporarily with LPS administration, but then rose thereafter. Administration of NE to the LPS group suppressed the transient decline in SMV blood flow, which did not drop below that of the control group. In the LPS group, jejunal mucosal tissue blood flow transiently dropped and then rose, reflecting the pattern in SMV blood flow. In the LPS+ NE group, however, although there was no drop in SMV blood flow, jejunal mucosal tissue blood flow remained low. An interaction between NE and LPS was observed regarding jejunal mucosal tissue blood flow from 90 to 180 min (P= 0.033). We showed that NE maintained MAP and SMV blood flow but decreased jejunal mucosal tissue blood flow. In a rabbit model of endotoxic shock, NE had a negative effect on jejunal mucosal tissue blood flow.
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