An exploratory case-only analysis of gene-hazardous air pollutant interactions and the risk of childhood medulloblastoma.
An exploratory case-only analysis of gene-hazardous air pollutant interactions and the risk of childhood medulloblastoma.
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DOI：
10.1002/pbc.24105
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发表时间：
2012-10
影响因子：
3.2
通讯作者：
Scheurer, Michael E.
中科院分区：
文献类型：
--
作者：
Lupo, Philip J.;Lee, Laura J.;Okcu, M. Fatih;Bondy, Melissa L.;Scheurer, Michael E.
关键词：
有证据表明，暴露于氯化溶剂可能与儿童髓母细胞瘤和原始神经外胚层肿瘤（M/PNET）的风险有关。动物模型表明，与解毒和DNA修复相关的基因在这些污染物的致癌性中起重要作用，然而，尚未有人类研究评估这些基因型对氯化溶剂与儿童M/PNET风险之间关系的修饰作用。我们进行了一项仅限病例的研究，以评估在解毒和DNA修复基因型的背景下，人口普查水平的氯化溶剂暴露和儿童M/PNET的风险。病例（n = 98）来自德克萨斯州儿童医院和MD安德森癌症中心。从Illumina Human 1M Quad SNP Chip中选择关键基因型（n = 22）。接触氯化溶剂（二氯甲烷、过氯乙烯、三氯乙烯和氯乙烯）是根据美国环保署1999年全国人口接触评估系统（ASPEN）估计的。采用Logistic回归估计病例优势比和95%置信区间（ci）。有11个显著的基因-环境相互作用与儿童M/PNET风险相关。然而，在校正多重比较后，只有高三氯乙烯水平与OGG1 rs293795之间的相互作用显著增加了儿童M/PNET风险（OR = 9.24, 95% CI: 2.24, 38.24, Q = 0.04）。本研究初步评估了环境氯溶剂水平与儿童M/PNET风险的潜在相关基因型之间的相互作用。我们的结果是探索性的，必须在动物模型和其他人体研究中得到验证。
There is evidence that exposure to chlorinated solvents may be associated with childhood medulloblastoma and primitive neuroectodermal tumor (M/PNET) risk. Animal models suggest genes related to detoxification and DNA repair are important in the carcinogenicity of these pollutants, however, there have been no human studies assessing the modifying effects of these genotypes on the association between chlorinated solvents and childhood M/PNET risk. We conducted a case-only study to evaluate census tract-level exposure to chlorinated solvents and the risk of childhood M/PNET in the context of detoxification and DNA repair genotypes. Cases (n = 98) were obtained from Texas Children’s Hospital and MD Anderson Cancer Center. Key genotypes (n = 22) were selected from the Illumina Human 1M Quad SNP Chip. Exposure to chlorinated solvents (methylene chloride, perchloroethylene, trichloroethylene, and vinyl chloride) was estimated from the U.S. EPA’s 1999 Assessment System for Population Exposure Nationwide (ASPEN). Logistic regression was used to estimate the case-only odds ratios and 95% confidence intervals (CIs). There were 11 significant gene-environment interactions associated with childhood M/PNET risk. However, after correcting for multiple comparisons, only the interaction between high trichloroethylene levels and OGG1 rs293795 significantly increased the risk of childhood M/PNET risk (OR = 9.24, 95% CI: 2.24, 38.24, Q = 0.04). This study provides an initial assessment of the interaction between ambient levels of chlorinated solvents and potentially relevant genotypes on childhood M/PNET risk. Our results are exploratory and must be validated in animal models, as well as additional human studies.
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DOI：
10.1097/01.jom.0000138913.75380.13
发表时间：
2004-09-01
影响因子：
3.2
作者：
Ali，R;Yu，CL;Christiani，DC
通讯作者：
Christiani，DC
影响因子：
56.9
作者：
PETERS, JM;PRESTONMARTIN, S;YU, MC
通讯作者：
YU, MC
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
6.2
作者：
Linabery, Amy M.;Ross, Julie A.
通讯作者：
Ross, Julie A.
影响因子：
3.5
作者：
HEINEMAN, EF;COCCO, P;BLAIR, A
通讯作者：
BLAIR, A