Using pictures and words to understand recognition memory deterioration in amnestic mild cognitive impairment and Alzheimer's disease: a review.

Using pictures and words to understand recognition memory deterioration in amnestic mild cognitive impairment and Alzheimer's disease: a review.
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DOI:
10.1007/s11910-012-0310-7
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发表时间:
2012-12
影响因子:
5.6
通讯作者:
Ally, Brandon A.
Ally, Brandon A.
中科院分区:
医学2区
文献类型:
--
作者:
Ally, Brandon A.

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难以识别以前遇到的刺激是早期阿尔茨海默病(AD)的最早迹象之一。在过去的10年里,工作集中在AD患者和遗忘型轻度认知障碍(aMCI)的前驱期患者如何对视觉和言语刺激做出识别决定。有趣的是,两组患者都表现出对图片的记忆明显好于文字,其程度明显高于健康的老年人。了解这种现象不仅有助于概念化AD中记忆如何崩溃,而且还可能为未来的干预提供基础。目前的审查将严格审查最近的识别记忆工作的背景下,使用图片和文字的双过程理论的识别和目前的假设认知崩溃的过程中,非常早期的AD。
Difficulty recognizing previously encountered stimuli is one of the earliest signs of incipient Alzheimer’s disease (AD). Work over the last 10 years has focused on how patients with AD and those in the prodromal stage of amnestic mild cognitive impairment (aMCI) make recognition decisions for visual and verbal stimuli. Interestingly, both groups of patients demonstrate markedly better memory for pictures over words, to a degree that is significantly greater in magnitude than their healthy older counterparts. Understanding this phenomenon not only helps to conceptualize how memory breaks down in AD, but also potentially provides the basis for future interventions. The current review will critically examine recent recognition memory work using pictures and words in the context of the dual-process theory of recognition and current hypotheses of cognitive breakdown in the course of very early AD.
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期刊: NEUROIMAGE
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