Developmental sex differences in resting state functional connectivity of amygdala sub-regions.
Developmental sex differences in resting state functional connectivity of amygdala sub-regions.
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DOI：
10.1016/j.neuroimage.2015.04.013
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发表时间：
2015-07-15
期刊：
影响因子：
5.7
通讯作者：
Nagel BJ
中科院分区：
文献类型：
--
作者：
Alarcón G;Cservenka A;Rudolph MD;Fair DA;Nagel BJ
在青春期，会发生大量的社会和生理变化，这些变化与大脑功能的成熟相互作用，其中一些具有性别特异性。杏仁核是一个表现出性别二态性的大脑区域，特别是在社会情感（浅杏仁核[SFA]）、应激（中央内侧杏仁核[CMA]）以及学习和记忆（基底外侧杏仁核[BLA]）处理方面。杏仁核还与情绪和焦虑障碍有关，这些障碍也表现出性别特异性特征，在青春期最为显著。本研究利用功能性磁共振成像（fMRI），在10 - 16岁的健康青少年样本（n = 122，71名男孩）中，研究了年龄和性别对杏仁核亚区（BLA和SFA）静息态功能连接（RSFC）的相互作用。进行了全脑、体素水平的偏相关分析，以确定双侧BLA和SFA种子区域的RSFC，这些种子区域是使用基于细胞构筑映射的艾克霍夫 - 齐勒斯最大概率图以及FMRIB的综合配准和分割工具（FIRST）创建的。采用蒙特卡罗模拟来校正多重比较（阈值为53个连续体素，z值≥2.25）。结果表明，随着年龄的增长，杏仁核两个亚区与顶枕叶皮质之间的RSFC相应降低，同时与内侧前额叶皮质（mPFC）的RSFC增加。具体而言，男孩和女孩分别随着年龄增长表现出mPFC与左右SFA耦合增加；然而，两种性别都没有显示出mPFC与BLA之间连接性增加，这可能表明额叶 - 边缘网络相对不成熟，且在性别间相似。BLA和SFA与顶枕叶的连接性出现分离，即随着年龄增长，女孩的SFA与顶枕叶区域之间的负性RSFC较弱，男孩的BLA与顶枕叶区域之间的负性RSFC较弱，这都与成人杏仁核亚区RSFC模式形成对比。本研究结果表明，青春期杏仁核亚区与顶枕叶皮质的RSFC相对不成熟，两种性别具有独特的模式，可能分别支持男孩和女孩的记忆和社会情感处理。了解青春期与杏仁核相关的大脑网络的潜在规范功能结构，可能会更好地为未来有关内化精神病理学风险增加相关的神经特征的研究提供信息。
During adolescence, considerable social and biological changes occur that interact with functional brain maturation, some of which are sex-specific. The amygdala is one brain area that has displayed sexual dimorphism, specifically in socio-affective (superficial amygdala [SFA]), stress (centromedial amygdala [CMA]), and learning and memory (basolateral amygdala [BLA]) processing. The amygdala has also been implicated in mood and anxiety disorders which also display sex-specific features, most prominently observed during adolescence. Using functional magnetic resonance imaging (fMRI), the present study examined the interaction of age and sex on resting state functional connectivity (RSFC) of amygdala sub-regions, BLA and SFA, in a sample of healthy adolescents between the ages 10-16 years (n=122, 71 boys). Whole-brain, voxel-wise partial correlation analyses were conducted to determine RSFC of bilateral BLA and SFA seed regions, created using the Eickhoff-Zilles maximum probability maps based on cytoarchitectonic mapping and FMRIB's Integrated Registration and Segmentation Tool (FIRST). Monte Carlo simulation was implemented to correct for multiple comparisons (threshold of 53 contiguous voxels with a z-value ≥ 2.25). Results indicated that with increasing age, there was a corresponding decrease in RSFC between both amygdala sub-regions and parieto-occipital cortices, with a concurrent increase in RSFC with medial prefrontal cortex (mPFC). Specifically, boys and girls demonstrated increased coupling of mPFC and left and right SFA with age, respectively; however, neither sex showed increased connectivity between mPFC and BLA, which could indicate relative immaturity of fronto-limbic networks that is similar across sex. A dissociation in connectivity between BLA- and SFA- parieto-occipital RSFC emerged, in which girls had weaker negative RSFC between SFA and parieto-occipital regions and boys had weaker negative RSFC of BLA and parieto-occipital regions with increased age, both standing in contrast to adult patterns of amygdala sub-regional RSFC. The present findings suggest relative immaturity of amygdala sub-regional RSFC with parieto-occipital cortices during adolescence, with unique patterns in both sexes that may support memory and socio-affective processing in boys and girls, respectively. Understanding the underlying normative functional architecture of brain networks associated with the amygdala during adolescence may better inform future research of the neural features associated with increased risk for internalizing psychopathology.
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影响因子：
2.6
作者：
Blackford, Jennifer Urbano;Clauss, Jacqueline A.;Avery, Suzanne N.;Cowan, Ronald L.;Benningfield, Margaret M.;VanDerKlok, Ross M.
通讯作者：
VanDerKlok, Ross M.
影响因子：
16.2
作者：
Euston DR;Gruber AJ;McNaughton BL
通讯作者：
McNaughton BL
影响因子：
2.5
作者：
Cunningham, MG;Bhattacharyya, S;Benes, FM
通讯作者：
Benes, FM
影响因子：
25.8
作者：
Cullen, Kathryn R.;Westlund, Melinda K.;Klimes-Dougan, Bonnie;Mueller, Bryon A.;Houri, Alaa;Eberly, Lynn E.;Lim, Kelvin O.
通讯作者：
Lim, Kelvin O.
影响因子：
11.3
作者：
Cservenka A;Casimo K;Fair DA;Nagel BJ
通讯作者：
Nagel BJ