Choline and betaine intake and risk of breast cancer among post-menopausal women.
Choline and betaine intake and risk of breast cancer among post-menopausal women.
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DOI：
10.1038/sj.bjc.6605510
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发表时间：
2010-02-02
影响因子：
8.8
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中科院分区：
文献类型：
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胆碱和甜菜碱与叶酸类似，是参与单碳代谢的营养物质，被认为可以降低患乳腺癌的风险。没有针对绝经后妇女的前瞻性研究检查了胆碱和甜菜碱摄入量与乳腺癌风险的关系。我们在护士健康研究中检查了74584名绝经后妇女的胆碱和甜菜碱摄入量与乳腺癌风险的关系。自1984年以来，使用有效的食物频率问卷对营养摄入量进行了六次评估。在从1984年到2004年的20年随访中，我们记录了3990例浸润性乳腺癌病例。总体而言，胆碱（平均±s.d； 326±61 mg /天）和甜菜碱（104±33 mg /天）摄入与绝经后乳腺癌风险降低无关。摄入量最高的五分位数的参与者的多变量相对风险为1.10(95%置信区间（95% CI）： 0.99-1.22；与摄入量最低的五分之一相比，胆碱的p值（趋势检验=0.14）和甜菜碱的p值（95% CI: 0.89-1.09； p值，趋势检验=0.96）分别为0.98和0.98。在按激素受体（雌激素受体/孕激素受体）状态分层的乳腺癌中，结果相似。胆碱摄入量与乳腺癌风险之间的关系并没有因酒精摄入量（不饮酒者，每天<15或15+ g）或其他乳腺癌风险因素（包括乳腺癌家族史、乳腺良性疾病史、体重指数、绝经后激素使用和叶酸摄入量）而有明显差异。我们没有发现证据表明高胆碱和甜菜碱摄入量可以降低绝经后妇女患乳腺癌的风险。
Choline and betaine, similar to folate, are nutrients involved in one-carbon metabolism and hypothesised to reduce breast cancer risk. No prospective study among post-menopausal women has examined choline and betaine intakes in relation to breast cancer risk. We examined the intake of choline and betaine and breast cancer risk among 74 584 post-menopausal women in the Nurses’ Health Study. Nutrient intake was assessed using a validated food-frequency questionnaire six times since 1984. During 20 years of follow-up from 1984 until 2004, we documented 3990 incident cases of invasive breast cancer. Overall, choline (mean±s.d.; 326±61 mg per day) and betaine (104±33 mg per day) intake was not associated with a reduced risk of post-menopausal breast cancer. Participants in the highest quintile of intakes had multivariate relative risks of 1.10 (95% confidence interval (95% CI): 0.99–1.22; P-value, test for trend=0.14) for choline and 0.98 (95% CI: 0.89–1.09; P-value, test for trend=0.96) for betaine, compared with those in the lowest quintiles of intakes. The results were similar in breast cancer stratified by hormone receptor (oestrogen receptor/progesterone receptor) status. The association between choline intake and breast cancer risk did not differ appreciably by alcohol intake (non-drinker, <15 or 15+ g per day) or several other breast cancer risk factors, including family history of breast cancer, history of benign breast disease, body mass index, post-menopausal hormone use, and folate intake. We found no evidence that higher intakes of choline and betaine reduce risk of breast cancer among post-menopausal women.
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