Choline: an essential nutrient for public health.
Choline: an essential nutrient for public health.
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DOI：
10.1111/j.1753-4887.2009.00246.x
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发表时间：
2009-11
影响因子：
6.1
通讯作者：
da Costa KA
中科院分区：
文献类型：
--
作者：
Zeisel SH;da Costa KA
胆碱于1998年被医学研究所（IOM）正式认定为必需营养素。人们对胆碱的膳食需求存在显著差异，这可以用常见的遗传多态性来解释。由于胆碱在人体代谢中的广泛作用，从细胞结构到神经递质合成，胆碱缺乏现在被认为对肝病、动脉粥样硬化和可能的神经紊乱等疾病有影响。胆碱存在于各种各样的食物中。蛋黄是美国人饮食中胆碱含量最高的来源，每100克蛋黄含有680毫克胆碱。年龄较大的儿童、男性、女性和孕妇的平均胆碱摄入量远远低于IOM确定的“适当摄入量”。鉴于胆碱在人体中广泛的关键功能中的重要性，加上人群中的最佳摄入量不足，应制定膳食指南以鼓励摄入富含胆碱的食物。
Choline was officially recognized as an essential nutrient by the Institute of Medicine (IOM) in 1998. There is a significant variation in the dietary requirement for choline that can be explained by common genetic polymorphisms. Because of its wide-ranging roles in human metabolism, from cell structure to neurotransmitter synthesis, choline-deficiency is now thought to have an impact on diseases such as liver disease, atherosclerosis and possibly neurological disorders. Choline is found in a wide variety of foods. Egg yolks are the most concentrated source of choline in the American diet, providing 680 milligrams per 100 grams. Mean choline intakes for older children, men, women and pregnant women are far below the Adequate Intake established by the IOM. Given the importance of choline in a wide range of critical functions in the human body, coupled with less than optimal intakes among the population, dietary guidance should be developed to encourage the intake of choline-rich foods.
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影响因子：
4.8
作者：
da Costa, Kerry-Ann;Kozyreva, Olga G.;Zeisel, Steven H.
通讯作者：
Zeisel, Steven H.
影响因子：
4.2
作者：
KIM, YI;MILLER, JW;MASON, JB
通讯作者：
MASON, JB
影响因子：
7.1
作者：
HolmesMcNary, MQ;Cheng, WL;Zeisel, SH
通讯作者：
Zeisel, SH
影响因子：
4.2
作者：
Jacob, RA;Jenden, DJ;Swendseid, ME
通讯作者：
Swendseid, ME
影响因子：
2
作者：
Cheng, Ruey-Kuang;MacDonald, Christopher J.;Meck, Warren H.
通讯作者：
Meck, Warren H.