Brain anatomical networks in early human brain development.

Brain anatomical networks in early human brain development.
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人类早期大脑发育中的大脑解剖网络

DOI:
10.1016/j.neuroimage.2010.07.025
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发表时间:
2011-02-01
期刊:
影响因子:
5.7
通讯作者:
Shen, Dinggang
Shen, Dinggang
中科院分区:
医学1区
文献类型:
--
作者:
Fan, Yong;Shi, Feng;Smith, Jeffrey Keith;Lin, Weili;Gilmore, John H.;Shen, Dinggang

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最近的神经成像研究表明,人脑网络具有经济的小世界拓扑结构和模块化组织,使得大脑区域之间能够进行高效的信息传输。然而,人类大脑网络的小世界拓扑和模块化组织是如何产生和发展的,在很大程度上仍然是未知的。利用28例1个月、1岁和2岁健康儿童的纵向MRI数据,分析了脑解剖网络的发育模式,并分析了脑区体积的形态相关性。结果表明,1月龄婴儿的脑网络具有典型的经济型小世界拓扑结构和非随机模块化结构。网络的成本效率随着大脑发育到1年和2年而增加,模块化也增加,这为脑网络的小世界拓扑和脑网络的模块化组织是在脑发育早期建立的假设提供了支持,以最小的重新布线成本支持快速同步和信息传输,并在局部处理和信息的全局整合之间取得平衡。
Recent neuroimaging studies have demonstrated that human brain networks have economic small-world topology and modular organization, enabling efficient information transfer among brain regions. However, it remains largely unknown how the small-world topology and modular organization of human brain networks emerge and develop. Using longitudinal MRI data of 28 healthy pediatric subjects, collected at their ages of 1 month, 1 year, and 2 years, we analyzed development patterns of brain anatomical networks derived from morphological correlations of brain regional volumes. The results show that the brain network of 1-month-olds has the characteristically economic small-world topology and nonrandom modular organization. The network’s cost efficiency increases with the brain development to 1 year and 2 years, so does the modularity, providing supportive evidence for the hypothesis that the small-world topology and the modular organization of brain networks are established during early brain development to support rapid synchronization and information transfer with minimal rewiring cost, as well as to balance between local processing and global integration of information.
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