Phosphorylation of the Regulators, a Complex Facet of NF-κB Signaling in Cancer.
Phosphorylation of the Regulators, a Complex Facet of NF-κB Signaling in Cancer.
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DOI：
10.3390/biom11010015
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发表时间：
2020-12-26
期刊：
影响因子：
5.5
通讯作者：
Lu T
中科院分区：
文献类型：
--
作者：
Motolani A;Martin M;Sun M;Lu T
核因子κ B（NF-κB）是一种普遍存在的转录因子，在人类炎症和各种恶性疾病中起重要作用。NF-κB的调节可受到大量翻译后修饰（PTM）的影响，包括磷酸化，这是NF-κB信号传导中最常见的PTM形式之一。通过磷酸化修饰的调节不仅限于NF-κB亚基，而且还包括NF-κB信号传导的多种调节剂。NF-κB自身或某些NF-κB调节因子的不同位点特异性磷酸化可导致NF-κB信号转导失调，通常最终导致诱发癌症进展和其他高NF-κB相关疾病，如炎症、心血管疾病、糖尿病以及神经退行性疾病等。我们讨论了磷酸化在NF-κB信号传导中的调节作用以及它们促进癌症进展的机制。此外，我们强调了一些已知的和新的NF-κB调节剂，经常受到磷酸化。最后，我们提供了一些未来的前景，在药物开发方面的目标激酶，调节NF-κB信号传导的癌症治疗的目的。
The nuclear factor kappa B (NF-κB) is a ubiquitous transcription factor central to inflammation and various malignant diseases in humans. The regulation of NF-κB can be influenced by a myriad of post-translational modifications (PTMs), including phosphorylation, one of the most popular PTM formats in NF-κB signaling. The regulation by phosphorylation modification is not limited to NF-κB subunits, but it also encompasses the diverse regulators of NF-κB signaling. The differential site-specific phosphorylation of NF-κB itself or some NF-κB regulators can result in dysregulated NF-κB signaling, often culminating in events that induce cancer progression and other hyper NF-κB related diseases, such as inflammation, cardiovascular diseases, diabetes, as well as neurodegenerative diseases, etc. In this review, we discuss the regulatory role of phosphorylation in NF-κB signaling and the mechanisms through which they aid cancer progression. Additionally, we highlight some of the known and novel NF-κB regulators that are frequently subjected to phosphorylation. Finally, we provide some future perspectives in terms of drug development to target kinases that regulate NF-κB signaling for cancer therapeutic purposes.
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影响因子：
7.3
作者：
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通讯作者：
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影响因子：
6
作者：
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通讯作者：
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影响因子：
4
作者：
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通讯作者：
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DOI：
10.1006/bbrc.1998.9224
发表时间：
1998-08-28
影响因子：
3.1
作者：
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通讯作者：
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DOI：
10.1158/1078-0432.ccr-09-1352
发表时间：
2009-10-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
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作者：
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通讯作者：
Van Waes C