Imaging techniques for visualizing and phenotyping congenital heart defects in murine models.
Imaging techniques for visualizing and phenotyping congenital heart defects in murine models.
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DOI：
10.1002/bdrc.21037
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发表时间：
2013-06
影响因子：
--
通讯作者：
Lo, Cecilia W.
中科院分区：
文献类型：
--
作者：
Liu, Xiaoqin;Tobita, Kimimasa;Francis, Richard J. B.;Lo, Cecilia W.
Mouse model is ideal for investigating the genetic and developmental etiology of congenital heart disease. However, cardiovascular phenotyping for the precise diagnosis of structural heart defects in mice remain challenging. With rapid advances in imaging techniques, there are now high throughput phenotyping tools available for the diagnosis of structural heart defects. In this review, we discuss the efficacy of four different imaging modalities for congenital heart disease diagnosis in fetal/neonatal mice, including noninvasive fetal echocardiography, micro-computed tomography (micro-CT), micro-magnetic resonance imaging (micro-MRI), and episcopic fluorescence image capture (EFIC) histopathology. The experience we have gained in the use of these imaging modalities in a large-scale mouse mutagenesis screen have validated their efficacy for congenital heart defect diagnosis in the tiny hearts of fetal and newborn mice. These cutting edge phenotyping tools will be invaluable for furthering our understanding of the developmental etiology of congenital heart disease.
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影响因子：
2.7
作者：
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通讯作者：
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影响因子：
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DOI：
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期刊：
ANATOMY AND EMBRYOLOGY
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影响因子：
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作者：
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通讯作者：
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