Slowed alpha oscillations and percept formation in psychotic psychopathology.
Slowed alpha oscillations and percept formation in psychotic psychopathology.
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DOI：
10.3389/fpsyg.2023.1144107
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发表时间：
2023
影响因子：
3.8
通讯作者：
Pokorny, Victor J. J.
中科院分区：
文献类型：
--
作者：
Sponheim, Scott R. R.;Stim, Joshua J. J.;Engel, Stephen A. A.;Pokorny, Victor J. J.
精神病的部分定义是知觉障碍。最近的研究表明，在脑电活动中观察到的α振荡的速度反映了视觉环境和感知的采样率。虽然减慢的α振荡和异常的视知觉形成在精神病性精神病理学障碍如精神分裂症中是明显的，但尚不清楚慢α振荡是否导致这些障碍中的异常视知觉。为了检查阿尔法振荡速度在精神病性精神病理学感知中的作用，我们收集了来自精神病性精神病理学先证者的静息态脑磁图数据（即，精神分裂症、情感性精神障碍和有精神病史的双相情感障碍）、他们的生物学兄弟姐妹和健康对照。我们通过一个简单的双眼竞争任务来评估视觉感知功能，而不混淆认知能力和努力。我们发现，在精神病性精神病理学中，α振荡的速度减慢，这与双眼竞争期间较长的感知持续时间有关，这与枕骨α振荡控制用于产生感知的视觉信息积累速率的说法一致。阿尔法速度在患有精神病性精神病理学的个体中变化很大，并且在几个月内高度稳定，这表明它可能是与视觉感知相关的神经功能的特征。最后，较低的α振荡速度与较低的智商和更大的障碍性痴呆相关，这意味着内源性神经振荡对视觉感知的影响可能对日常功能产生更广泛的影响。患有精神病性精神病理学的个体中缓慢的阿尔法振荡似乎反映了与感知形成相关的神经功能的改变。
Psychosis is in part defined by disturbances in perception. Recent investigations have implicated the speed of alpha oscillations observed in brain electrical activity as reflective of a sampling rate of the visual environment and perception. Although both slowed alpha oscillations and aberrant percept formation are evident in disorders of psychotic psychopathology such as schizophrenia it is unclear whether slow alpha accounts for abnormal visual perception in these disorders. To examine the role of the speed of alpha oscillations in perception in psychotic psychopathology we gathered resting-state magneto-encephalography data from probands with psychotic psychopathology (i.e., schizophrenia, schizoaffective disorder, and bipolar disorder with a history of psychosis), their biological siblings, and healthy controls. We appraised visual perceptual function without the confound of cognitive ability and effort through the use of a simple binocular rivalry task. We found a slowed pace of alpha oscillations in psychotic psychopathology that was associated with longer percept durations during binocular rivalry, consistent with the assertion that occipital alpha oscillations govern the rate of accumulation of visual information used to generate percepts. Alpha speed varied widely across individuals with psychotic psychopathology and was highly stable across several months indicating that it is likely a trait characteristic of neural function that is relevant to visual perception. Finally, a lower speed of alpha oscillation was associated with a lower IQ and greater disorder symptomatology implying that the effects of the endogenous neural oscillation on visual perception may have wider consequences for everyday functioning. Slowed alpha oscillations in individuals with psychotic psychopathology appear to reflect altered neural functions related to percept formation.
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通讯作者：
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