White matter tracts characteristics in habitual decision-making circuit underlie ritual behaviors in anorexia nervosa.
White matter tracts characteristics in habitual decision-making circuit underlie ritual behaviors in anorexia nervosa.
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习惯决策回路中的白质特征是神经性厌食症的仪式行为。
DOI：
10.1038/s41598-021-95300-3
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发表时间：
2021-08-05
影响因子：
4.6
通讯作者：
Feusner JD
中科院分区：
文献类型：
--
作者：
Tadayonnejad R;Pizzagalli F;Murray SB;Pauli WM;Conde G;Bari AA;Strober M;O'Doherty JP;Feusner JD
神经性厌食症 (AN) 是一种难以治疗的恶性精神疾病，与决策异常有关。作为一项解释性子研究，我们在成人和青少年的两个独立数据集中检查了 32 个 AN 和 43 个健康对照的习惯性和目标导向决策回路的结构特征及其连接的白质束。相对于对照组，成人 AN 患者习惯回路中的双侧前运动区/辅助运动区 - 壳核束的总体积显着更高。在患有 AN 的成人和青少年中，习惯回路中的束数和白质体积 (WMV) 与仪式/强迫行为的严重程度之间存在正相关。此外，我们发现习惯回路 WMV 对仪式/强迫症状严重程度有显着影响，具体取决于关注症状的严重程度。这些发现表明 AN 与习惯回路中白质可塑性的改变有关。习惯回路白质束的特征与 AN 行为症状之间的关联为基于回路的 AN 神经生物学模型提供了支持，并将习惯回路确定为进一步研究的焦点，以帮助开发基于大脑行为关系的新颖且更有效的治疗方法。
Anorexia nervosa (AN) is a difficult to treat, pernicious psychiatric disorder that has been linked to decision-making abnormalities. We examined the structural characteristics of habitual and goal-directed decision-making circuits and their connecting white matter tracts in 32 AN and 43 healthy controls across two independent data sets of adults and adolescents as an explanatory sub-study. Total bilateral premotor/supplementary motor area-putamen tracts in the habit circuit had a significantly higher volume in adults with AN, relative to controls. Positive correlations were found between both the number of tracts and white matter volume (WMV) in the habit circuit, and the severity of ritualistic/compulsive behaviors in adults and adolescents with AN. Moreover, we found a significant influence of the habit circuit WMV on AN ritualistic/compulsive symptom severity, depending on the preoccupations symptom severity levels. These findings suggest that AN is associated with white matter plasticity alterations in the habit circuit. The association between characteristics of habit circuit white matter tracts and AN behavioral symptoms provides support for a circuit based neurobiological model of AN, and identifies the habit circuit as a focus for further investigation to aid in development of novel and more effective treatments based on brain-behavior relationships.
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