From elementary synaptic circuits to information processing in primary auditory cortex.
From elementary synaptic circuits to information processing in primary auditory cortex.
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DOI：
10.1016/j.neubiorev.2011.05.004
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发表时间：
2011-11
影响因子：
8.2
通讯作者：
Zhang, Li I.
中科院分区：
文献类型：
--
作者：
Wu, Guangying K.;Tao, Huizhong W.;Zhang, Li I.
关键词：
要了解信息是如何在大脑皮层中处理的，关键是要解开极其复杂的大脑皮层神经回路。最近的技术创新，特别是体内全细胞电压钳记录技术，使得直接解剖单个皮质神经元处理功能背后的兴奋性和抑制性输入成为可能。该方法为传统方法提供了必要的补充，传统方法通过将神经元尖峰输出与感觉输入相关联来推导神经系统的传递函数。在这里，我们打算介绍一种潜在的系统策略来解决功能性突触电路的结构。由于复杂电路可以建立在基本模块上，该策略的主要重点是识别基本突触电路，并确定这些电路单元如何促进特定的处理功能。本文将对初级听觉皮层功能性突触回路的最新研究进行综述，对现有的体内回路研究实验技术进行评述，并对近期的研究方向进行展望。
A key for understanding how information is processed in the cortex is to unravel the dauntingly complex cortical neural circuitry. Recent technical innovations, in particular the in vivo whole-cell voltage-clamp recording techniques, make it possible to directly dissect the excitatory and inhibitory inputs underlying an individual cortical neuron’s processing function. This method provides an essential complement to conventional approaches, with which the transfer functions of the neural system are derived by correlating neuronal spike outputs to sensory inputs. Here, we intend to introduce a potentially systematic strategy for resolving the structure of functional synaptic circuits. As complex circuits can be built upon elementary modules, the primary focus of this strategy is to identify elementary synaptic circuits and determine how these circuit units contribute to specific processing functions. This review will summarize recent studies on functional synaptic circuits in the primary auditory cortex, comment on existing experimental techniques for in vivo circuitry studies, and provide a perspective on immediate future directions.
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影响因子：
25
作者：
Bandyopadhyay, Sharba;Shamma, Shihab A.;Kanold, Patrick O.
通讯作者：
Kanold, Patrick O.
DOI：
10.1523/jneurosci.2093-08.2008
发表时间：
2008-10-29
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
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通讯作者：
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作者：
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通讯作者：
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影响因子：
64.8
作者：
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影响因子：
5.5
作者：
COOMBS, JS;ECCLES, JC;FATT, P
通讯作者：
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