Risk factors for sleep-disordered breathing in pregnancy.
Risk factors for sleep-disordered breathing in pregnancy.
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DOI：
10.1136/thoraxjnl-2012-202718
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发表时间：
2014-04
期刊：
影响因子：
10
通讯作者：
Schwab RJ
中科院分区：
文献类型：
--
作者：
Pien GW;Pack AI;Jackson N;Maislin G;Macones GA;Schwab RJ
睡眠呼吸障碍（SDB）的症状在孕妇中很常见，一些研究将SDB症状与妊娠期高血压和先兆子痫联系起来。然而，很少有前瞻性研究客观测量SDB在怀孕期间进行。我们进行了一项前瞻性队列研究，检查孕妇妊娠晚期SDB的危险因素。来自宾夕法尼亚大学医院产科实践的105名孕妇完成了第一和第三个三个月的夜间多导睡眠图研究。我们研究了在怀孕期间每小时睡眠中睡眠呼吸障碍事件的数量是否增加。我们进行了未经调整的多变量逻辑回归分析，以估计一般和妊娠特异性特征对晚期OSA发展的影响。在二次分析中，我们研究了客观测量的SDB、妊娠期高血压疾病和其他不良母儿结局之间的关系。平均AHI从基线（妊娠早期）的2.07（SD 3.01）起事件/小时增加至妊娠晚期的3.74（SD 5.97）起（p=0.009）。10.5%的女性在妊娠早期患有OSA。到了第三个三个月，26.7%的女性患有OSA。在多变量分析中，孕早期BMI和母亲年龄与孕晚期OSA显著相关。三个月的OSA很常见。无基线SDB的妇女中晚期妊娠OSA的危险因素包括较高的基线BMI和母亲年龄。
Symptoms of sleep-disordered breathing (SDB) are common among pregnant women, and several studies link SDB symptoms with gestational hypertension and preeclampsia. However, few prospective studies objectively measuring SDB during pregnancy have been performed. We performed a prospective cohort study examining risk factors for third trimester SDB in pregnant women. 105 pregnant women from the Hospital of the University of Pennsylvania obstetrics practices completed first and third trimester overnight polysomnography studies. We examined whether the number of sleep-disordered breathing events per hour of sleep increased during pregnancy. We performed unadjusted and multivariable logistic regression analyses to estimate the effects of usual and pregnancy-specific characteristics on development of third trimester OSA. In secondary analyses, we examined the relationship between objectively measured SDB, hypertensive disorders of pregnancy, and other adverse maternal-fetal outcomes. Mean AHI increased from 2.07 (SD 3.01) events/hour at baseline (first trimester) to 3.74 (SD 5.97) in the third trimester (p=0.009). 10.5% of women had OSA in the first trimester. By the third trimester, 26.7% of women had OSA. In multivariable analyses, first trimester BMI and maternal age were significantly associated with third trimester OSA. Third trimester OSA is common. Risk factors for third trimester OSA among women without baseline SDB include higher baseline BMI and maternal age.
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影响因子：
9.6
作者：
Loube, DI;Poceta, JS;Mitler, MM
通讯作者：
Mitler, MM
DOI：
10.1164/ajrccm/144.2.461
发表时间：
1991-08-01
期刊：
AMERICAN REVIEW OF RESPIRATORY DISEASE
影响因子：
--
作者：
CHARBONNEAU, M;FALCONE, T;LEVY, RD
通讯作者：
LEVY, RD
DOI：
10.1186/1472-6874-10-17
发表时间：
2010-05-14
期刊：
BMC women's health
影响因子：
--
作者：
Qiu C;Enquobahrie D;Frederick IO;Abetew D;Williams MA
通讯作者：
Williams MA
影响因子：
24.3
作者：
Connolly, G;Razak, ARA;McNicholas, WT
通讯作者：
McNicholas, WT
影响因子：
24.3
作者：
Bourjeily, G.;Raker, C. A.;Miller, M. A.
通讯作者：
Miller, M. A.