Interplay between sex determination cascade and major signaling pathways during Drosophila eye development: Perspectives for future research.
Interplay between sex determination cascade and major signaling pathways during Drosophila eye development: Perspectives for future research.
复制标题
性别确定级联和主要信号通路之间的相互作用在果蝇眼发育过程中：未来研究的观点。
DOI：
10.1016/j.ydbio.2021.03.005
复制
发表时间：
2021-08
影响因子：
2.7
通讯作者：
Samsonova M
中科院分区：
文献类型：
--
作者：
Surkova S;Görne J;Nuzhdin S;Samsonova M
了解性二态性器官生长的分子机制是发育生物学的一个基本问题。最近的定量研究表明，果蝇复眼是研究确定最终器官大小的便捷模型。在果蝇中，雌性的眼睛比雄性大，即使在对较大的体型进行校正后，这一点仍然很明显。此外，雌性眼睛比雄性眼睛包含更多的小眼（光敏单位），这种差异在眼原基中的第三龄幼虫处被指定，称为眼成虫盘。这可能会导致两性之间视觉能力不同，并产生行为后果。尽管越来越多的证据表明不同果蝇物种和品系之间眼睛大小差异的遗传基础，但导致物种内两性二态性的机制仍然难以捉摸。在这里，我们讨论了二态性眼睛发育过程中性别决定级联和主要信号通路之间的假定串扰。已知 Doublesex (Dsx) 蛋白的男性和女性特异性亚型可控制体细胞组织中的性别特异性分化。然而，目前还没有关于眼盘生长和图案化过程中 Dsx 功能的数据。值得注意的是，性别决定开关蛋白 Sex lethal (Sxl) 被证明可以直接影响果蝇翼盘中的 Hedgehog (Hh) 和 Notch (N) 信号传导。翅膀和眼盘生长所涉及的信号通路的相似性表明，Sxl 可能整合到眼睛发育的调节中。 DSX 在眼盘中的作用需要进一步研究。我们讨论了果蝇眼睛中性别偏见基因表达的现有数据，并强调了未来研究的前景。
Understanding molecular mechanisms of sexually dimorphic organ growth is a fundamental problem of developmental biology. Recent quantitative studies showed that the Drosophila compound eye is a convenient model to study the determination of the final organ size. In Drosophila, females have larger eyes than males and this is evident even after correction for the larger body size. Moreover, female eyes include more ommatidia (photosensitive units) than male eyes and this difference is specified at the third larval instar in the eye primordia called eye imaginal discs. This may result in different visual capabilities between the two sexes and have behavioral consequences. Despite growing evidence on the genetic bases of eye size variation between different Drosophila species and strains, mechanisms responsible for within-species sexual dimorphism still remain elusive. Here, we discuss a presumptive crosstalk between the sex determination cascade and major signaling pathways during dimorphic eye development. Male- and female-specific isoforms of Doublesex (Dsx) protein are known to control sex-specific differentiation in the somatic tissues. However, no data on Dsx function during eye disc growth and patterning are currently available. Remarkably, Sex lethal (Sxl), the sex determination switch protein, was shown to directly affect Hedgehog (Hh) and Notch (N) signaling in the Drosophila wing disc. The similarity of signaling pathways involved in the wing and eye disc growth suggests that Sxl might be integrated into regulation of eye development. Dsx role in the eye disc requires further investigation. We discuss currently available data on sex-biased gene expression in the Drosophila eye and highlight perspectives for future studies.
登录
查看更多内容
影响因子：
2.7
作者：
BRYANT, PJ;LEVINSON, P
通讯作者：
LEVINSON, P
影响因子：
10.7
作者：
Buchberger E;Bilen A;Ayaz S;Salamanca D;Matas de Las Heras C;Niksic A;Almudi I;Torres-Oliva M;Casares F;Posnien N
通讯作者：
Posnien N
影响因子：
4.6
作者：
Chatterjee, Sujash S.;Uppendahl, Locke D.;Siegal, Mark L.
通讯作者：
Siegal, Mark L.
DOI：
10.1098/rspb.2019.2765
发表时间：
2020-03-25
影响因子：
4.7
作者：
Chowdhury, Tabashir;Calhoun, Ryan M.;Moehring, Amanda J.
通讯作者：
Moehring, Amanda J.
解码 Hedgehog 信号转导中的磷酸化密码
影响因子：
44.1
作者：
通讯作者：
--