Vasopressin does not mediate hypersensitivity of the hypothalamic pituitary adrenal axis during chronic stress.
Vasopressin does not mediate hypersensitivity of the hypothalamic pituitary adrenal axis during chronic stress.
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DOI：
10.1196/annals.1410.037
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发表时间：
2008-12
影响因子：
5.2
通讯作者：
Aguilera, Greti
中科院分区：
文献类型：
--
作者：
Chen, Jun;Young, Sharla;Subburaju, Sivan;Sheppard, Jack;Kiss, Alexander;Atkinson, Helen;Wood, Susan;Lightman, Stafford;Gal, Claudine Serradeil-Le;Aguilera, Greti
通过观察药物性VP受体阻断剂对14天反复束缚大鼠ACTH和皮质酮反应的影响，验证了在慢性下丘脑垂体肾上腺（HPA）激活过程中，加压素（VP）成为垂体促肾上腺皮质激素反应的主要介质的假设。尽管增加的血管加压素能活性，反复克制大鼠表现出较低的ACTH和皮质酮的反应，10分钟白色噪音相比，处理控制。非肽选择性V1 b受体拮抗剂，SSR 149415，i. v.，噪声应用前1小时。与噪声应激相反，与处理对照组相比，重复束缚大鼠对腹腔注射高渗盐水的血浆ACTH反应增强，但在束缚前1 h每日经口给予SSR 149415也不影响反应。由于SSR 149415的有效性较低，我们使用肽V1受体拮抗剂dGly[Phaa，D-Tyr（et），Lys，Arg]VP（V1-Ant）的微泵输注14天，其有效地阻断了ACTH对外源性VP的反应。慢性V1-Ant输注降低了处理对照组中对腹膜内高渗盐水的血浆ACTH反应，但在反复限制的大鼠中没有。这些数据表明，增加的加压素活性特征的慢性应激发挥的作用，而不是介导的HPA轴的超敏反应，以一种新的压力。
The hypothesis that vasopressin (VP) becomes the main mediator of pituitary corticotroph responsiveness during chronic hypothalamic pituitary adrenal (HPA) activation, was tested by examining the effect of pharmacologic VP receptor blockade on the ACTH and corticosterone responses of 14-day repeatedly restrained rats. In spite of the increased vasopressinergic activity, repeatedly restrained rats showed lower ACTH and corticosterone responses to 10 min white noise compared with handled controls. These responses were unchanged by the non-peptide selective V1b receptor antagonist, SSR149415, i.v., 1h before noise application. In contrast to noise stress, plasma ACTH responses to i.p. hypertonic saline injection were enhanced in the repeatedly restrained rats compared with handled controls but responses were also unaffected by SSR149415 administered orally, daily 1 h before restraint. Since SSR149415 effectiveness was low, we used minipump infusion of the peptide V1 receptor antagonist, dGly[Phaa,D-Tyr(et), Lys, Arg]VP (V1-Ant) for 14 days, which effectively blocked ACTH responses to exogenous VP. Chronic V1-Ant infusion reduced plasma ACTH responses to i.p. hypertonic saline in handled controls but not in repeatedly restrained rats. These data suggest that the increased vasopressinergic activity characteristic of chronic stress plays roles other than mediating the hypersensitivity of the HPA axis to a novel stress.
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影响因子：
7.3
作者：
CHOWDREY, HS;LARSEN, PJ;LIGHTMAN, SL
通讯作者：
LIGHTMAN, SL
影响因子：
4.8
作者：
IRVINE, CHG;ALEXANDER, SL;DONALD, RA
通讯作者：
DONALD, RA
影响因子：
3.2
作者：
Lolait SJ;Stewart LQ;Roper JA;Harrison G;Jessop DS;Young WS 3rd;O'Carroll AM
通讯作者：
O'Carroll AM
影响因子：
4.8
作者：
Ma, XM;Lightman, SL;Aguilera, G
通讯作者：
Aguilera, G
影响因子：
4.8
作者：
AGUILERA, G;LIGHTMAN, SL;KISS, A
通讯作者：
KISS, A