Early effects of prostaglandin E2 on bone formation and resorption in different bone sites of rats.
Early effects of prostaglandin E2 on bone formation and resorption in different bone sites of rats.
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前列腺素E2对大鼠不同骨部位骨形成和吸收的早期影响。
DOI：
10.1016/8756-3282(95)00300-3
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发表时间：
1995
期刊：
影响因子：
4.1
通讯作者：
Setterberg,RB
中科院分区：
文献类型：
--
作者：
Lin,CH;Jee,WS;Ma,YF;Setterberg,RB
本研究的目的是通过组织形态学分析确定前列腺素E2（PGE 2）对生长松质骨部位（胫骨近端干骺端，PTM）、非生长松质骨部位（胫骨远端干骺端，DTM）和皮质骨部位（胫骨干，TX）骨量、形成和吸收的早期影响。皮下注射6 mg PGE 2/kg/d。给6月龄Sprague-Dawley雌性大鼠5、10或16天。PGE 2治疗0、10、16 d组和16 d对照组给予双荧光标记。治疗16天后，在松质骨部位发现骨量显著增加，但在皮质骨部位未发现。早在治疗后5天，在所有3个骨部位均观察到刺激骨形成，表现为类骨质周长增加。治疗10天后，骨形成指数增加，然而，在所有3个骨部位，10天和16天PGE 2治疗之间的选定骨形成指数没有差异。治疗5 d后，松质骨部位的侵蚀表面和类骨质覆盖的侵蚀表面显著增加，但治疗10 d后减少。在第5天，TX的侵蚀表面没有增加，但皮质内表面的侵蚀表面被类骨质覆盖，这表明在第5天之前，PGE 2刺激覆盖在该表面上。结论：PGE_2早在治疗后5天就能刺激骨形成和骨吸收。刺激成骨水平为TX>DTM>PTM。骨吸收水平为DTM>PTM>TX。骨形成超过骨吸收，净骨平衡为正。这些发现表明，需要更早的时间段和细胞水平机制研究来表征PGE 2的早期作用。
The aim of this study was to determine early effects of prostaglandin E2(PGE2) on bone mass, formation and resorption in a growing cancellous bone site (the proximal tibial metaphysis, PTM), non-growing cancellous bone site (the distal tibial metaphysis, DTM), and cortical bone site (the tibial shaft, TX) with histomorphometric analysis. Six mg PGE2/kg/d was given s.c. to 6-month-old Sprague-Dawley female rats for 5, 10 or 16 days. Double fluorescent labels were given to 0, 10- and 16-day PGE2treatment and 16-day control groups. Significant increase in bone mass was found after 16 days treatment in cancellous bone sites but not in the cortical bone site. Stimulated bone formation, indicated by the increase in osteoid perimeter, was observed as early as 5 days post-treatment in all 3 bone sites. Bone formation indices were increased after 10 days of treatment, however, there was no difference in selected bone formation indices between 10 and 16 days PGE2treatments at all 3 bone sites. Significant increase in eroded surface and eroded surface covered with osteoid was observed in cancellous bone sites after 5 days, but decreased after 10 days of treatment. Although the eroded surface was not elevated in TX at the 5th day, the eroded surface covered with osteoid was increased on endocortical surface which indicated that PGE2stimulated covered with on this surface prior to day 5. We concluded that PGE2stimulated the bone formation and resorption as early as 5 days post-treatment. The levels of stimulated bone formation was TX>DTM>PTM. The levels of bone resorption was DTM>PTM>TX. Bone formation exceeded bone resorption and the net bone balance was positive. These findings indicate that earlier time periods and cell-level mechanism studies are needed to characterize the early effects of PGE2.
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前列腺素 E2 在卵巢切除大鼠的生长板闭合且骨转换率低的松质骨部位添加骨骼。
影响因子：
4.1
作者：
Ma,YF;Ke,HZ;Jee,WS
通讯作者：
Jee,WS
大鼠成人松质骨部位对前列腺素 E2 的合成代谢反应。
DOI：
10.1016/s0169-6009(08)80232-2
发表时间：
1993
期刊：
Bone and mineral
影响因子：
--
作者：
Ito,H;Ke,HZ;Jee,WS;Sakou,T
通讯作者：
Sakou,T
老年松质骨部位比年轻松质骨部位发生更大的骨形成诱导。
影响因子：
4.1
作者：
Ke,HZ;Jee,WS;Ito,H;Setterberg,RB;Li,M;Lin,BY;Liang,XG;Ma,YF
通讯作者：
Ma,YF
DOI：
10.1016/0169-6009(91)90109-d
发表时间：
1991-10-01
期刊：
BONE AND MINERAL
影响因子：
--
作者：
JEE, WSS;KE, HZ;LI, XJ
通讯作者：
LI, XJ
前列腺素 F2 α 对培养的新生小鼠颅骨骨形成和吸收的影响：前列腺素 E2 产生的作用。
影响因子：
4.8
作者：
Raisz,LG;Alander,CB;Fall,PM;Simmons,HA
通讯作者：
Simmons,HA