Elevated plasma corticosterone level and depressive behavior in experimental temporal lobe epilepsy.
Elevated plasma corticosterone level and depressive behavior in experimental temporal lobe epilepsy.
复制标题
实验性颞叶癫痫中血浆皮质酮水平升高和抑郁行为。
DOI：
10.1016/j.nbd.2009.02.018
复制
发表时间：
2009-06
影响因子：
6.1
通讯作者：
Sankar R
中科院分区：
文献类型：
--
作者：
Mazarati AM;Shin D;Kwon YS;Bragin A;Pineda E;Tio D;Taylor AN;Sankar R
癫痫患者经常出现抑郁症。然而，人们对癫痫和抑郁症共病的机制知之甚少。抑郁症的一个重要机制是下丘脑-垂体-肾上腺皮质（HPA）轴内的去抑制。我们检查了颞叶癫痫和抑郁症共病大鼠模型中 HPA 轴的功能状态。癫痫伴有发作间期血浆皮质酮升高，以及地塞米松/促肾上腺皮质激素释放激素联合试验阳性。 HPA 过度活跃的程度与复发性癫痫发作无关，但与抑郁行为的严重程度呈正相关。我们认为观察到的 HPA 轴过度活跃可能是癫痫和抑郁症并存的基础。
Depression is frequently reported in epilepsy patients; however, mechanisms of co-morbidity between epilepsy and depression are poorly understood. An important mechanism of depression is disinhibition within the hypothalamo-pituitary-adrenocortical (HPA) axis. We examined the functional state of the HPA axis in a rat model of co-morbidity between temporal lobe epilepsy and depression. Epilepsy was accompanied by the interictal elevation of plasma corticosterone, and by the positive combined dexamethasone/corticotropin releasing hormone test. The extent of the HPA hyperactivity was independent of recurrent seizures, but positively correlated with the severity of depressive behavior. We suggest that the observed hyperactivity of the HPA axis may underlie co-morbidity between epilepsy and depression.
登录
查看更多内容
影响因子：
5.6
作者：
Bragin, A;Wilson, CL;Engel, T
通讯作者：
Engel, T
影响因子：
7.6
作者：
Leitch, MM;Ingram, CD;Gartside, SE
通讯作者：
Gartside, SE
DOI：
10.1016/b978-012088554-1/50030-x
发表时间：
2006-01-01
期刊：
MODELS OF SEIZURES AND EPILEPSY
影响因子：
--
作者：
McIntyre, Dan C.
通讯作者：
McIntyre, Dan C.
DOI：
10.1073/pnas.1034823100
发表时间：
2003-05-13
影响因子：
11.1
作者：
El Yacoubi, M;Bouali, S;Vaugeois, JM
通讯作者：
Vaugeois, JM
影响因子：
2.6
作者：
Mazarati, Andrey;Shin, Don;Sankar, Raman
通讯作者：
Sankar, Raman