Newborn mice form lasting CA2-dependent memories of their mothers.
Newborn mice form lasting CA2-dependent memories of their mothers.
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DOI：
10.1016/j.celrep.2020.108668
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发表时间：
2021-01-26
期刊：
影响因子：
8.8
通讯作者：
Gould E
中科院分区：
文献类型：
--
作者：
Laham BJ;Diethorn EJ;Gould E
一些最持久的社会关系始于婴儿第一次认出他们的照顾者，这些记忆构成了许多家庭关系的基础。目前尚不清楚小鼠的这些早期社会记忆是否会持续到成年，如果是的话，哪些大脑区域支持它们。在这里，我们展示了老鼠在出生后的几天内形成了对它们母亲的记忆，并且这些记忆一直持续到成年。幼崽在断奶前对母亲表现出更大的兴趣，而在断奶后，这种偏好就会逆转。幼崽体内CA2神经元的抑制暂时阻止了区分母亲和不熟悉的母犬的能力，而在成年后，这样做会阻止形成关于相同细节的短期记忆，以及与母亲的长期记忆相关的社会歧视。这些结果表明，CA2支持母亲在婴儿期和成年期的记忆，并伴随着社会偏好的发展变化。Laham等人。报告说，老鼠认出了它们的照料母亲，并通过断奶后社会偏好的逆转将它们与新妈妈区分开来。作为对母亲刺激的反应，CA2区的即刻早期基因表达与社会偏好相一致。抑制CA2会损害幼崽和成年幼崽照顾母亲的记忆。
Some of the most enduring social connections begin when infants first recognize their caregivers, memories that form the basis of many family relationships. It remains unknown whether these early social memories persist into adulthood in mice and, if so, which brain regions support them. Here we show that mice form memories of their mother within days after birth and that these memories persist into adulthood. Pups display greater interest in the mother than in an unfamiliar dam before weaning, after which this preference reverses. Inhibition of CA2 neurons in the pup temporarily blocks the ability to discriminate between the mother and an unfamiliar dam, whereas doing so in adulthood prevents the formation of short-term memories about conspecifics, as well as social discrimination related to long-term memories of the mother. These results suggest that the CA2 supports memories of the mother during infancy and adulthood with a developmental switch in social preference. Laham et al. report that mice recognize their caregiving mothers and distinguish them from novel mothers with a postweaning reversal in social preference. In response to mother stimuli, immediate-early gene expression in the CA2 parallels social preference. CA2 inhibition impairs memory for the caregiving mother in pups and adults.
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DOI：
10.1038/nrn.2015.22
发表时间：
2016-02
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Dudek SM;Alexander GM;Farris S
通讯作者：
Farris S
社会和新颖的环境修改了海马CA2空间的表示。
影响因子：
16.6
作者：
Alexander GM;Farris S;Pirone JR;Zheng C;Colgin LL;Dudek SM
通讯作者：
Dudek SM
影响因子：
5.7
作者：
Carstens KE;Dudek SM
通讯作者：
Dudek SM
影响因子：
4.8
作者：
Cymerblit-Sabba, Adi;Smith, Adam S.;Young, W. Scott
通讯作者：
Young, W. Scott
影响因子：
2.6
作者：
DAMATO, FR
通讯作者：
DAMATO, FR