Durability of Viral Neutralization in Asymptomatic Coronavirus Disease 2019 for at Least 60 Days.

Durability of Viral Neutralization in Asymptomatic Coronavirus Disease 2019 for at Least 60 Days.
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DOI:
10.1093/infdis/jiab140
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发表时间:
2021-05-28
期刊:
The Journal of infectious diseases
影响因子:
--
通讯作者:
deFilippi CR
deFilippi CR
中科院分区:
其他
文献类型:
--
作者:
Haymond A;Damluji AA;Narayanan A;Mueller C;Reeder A;Alem F;Maxwell GL;Petricoin EF;Liotta L;deFilippi CR

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由无症状医护人员组成的队列在感染严重急性呼吸综合征冠状病毒2后捐献了颞叶血清样本。分析显示,所有无症状医护人员都有中和抗体,这些抗体持续≥60天,并且抗尖峰受体结合域免疫球蛋白G水平在同一时间段内相应持久。通过 BSL-3 病毒斑块减少中和测试,感染严重急性呼吸综合征冠状病毒 2 型的无症状医护人员从基线到 60 天都显示出持久的病毒中和滴度。抗受体结合域免疫球蛋白 G 在此期间也具有持久性。
A cohort consisting of asymptomatic healthcare workers donated temporal serum samples after infection with severe acute respiratory syndrome coronavirus 2. Analysis shows that all asymptomatic healthcare workers had neutralizing antibodies, that these antibodies persist for ≥60 days, and that anti-spike receptor-binding domain immunoglobulin G levels were correspondingly durable over the same time period. Asymptomatic healthcare workers infected with severe acute respiratory syndrome coronavirus 2 show durable viral neutralization titers from baseline to 60 days with a BSL-3 viral plaque reduction neutralization test. Anti–receptor-binding domain immunoglobulin G is also durable during this time.
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