Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in Drug Development.
Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in Drug Development.
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DOI：
10.1016/j.stem.2018.02.011
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发表时间：
2018-03-01
期刊：
影响因子：
23.9
通讯作者：
Vunjak-Novakovic G
中科院分区：
文献类型：
--
作者：
Ronaldson-Bouchard K;Vunjak-Novakovic G
芯片上的器官（OOC）是在体外培养的微型组织和器官，可以模拟人体生理和疾病。这项技术是在组织工程、半导体制造和人类细胞来源方面取得进步的结果。包括人类干细胞技术的创新，OOCs提供了一种有前途的方法来模拟体外的人类病理/生理，并解决了当前细胞和动物模型的局限性。在这里，我们回顾了单器官和多器官occ的设计考虑，讨论了仍然存在的挑战，并强调了ooc作为组织工程推进药物开发和精准医疗的快速通道的潜在影响。
Organs on a Chip (OOC) are miniature tissues and organs grown in vitro that enable modeling of human physiology and disease. The technology has emerged from converging advances in tissue engineering, semiconductor fabrication, and human cell sourcing. Encompassing innovations in human stem cell technology, OOCs offer a promising approach to emulate human patho/physiology in vitro, and address limitations of current cell and animal models. Here, we review the design considerations for single and multi-organ OOCs, discuss remaining challenges, and highlight the potential impact of OOCs as a fast-track opportunity for tissue engineering to advance drug development and precision medicine.
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影响因子：
6.1
作者：
Godoy, Patricio;Hewitt, Nicola J.;Albrecht, Ute;Andersen, Melvin E.;Ansari, Nariman;Bhattacharya, Sudin;Bode, Johannes Georg;Bolleyn, Jennifer;Borner, Christoph;Boettger, Jan;Braeuning, Albert;Budinsky, Robert A.;Burkhardt, Britta;Cameron, Neil R.;Camussi, Giovanni;Cho, Chong-Su;Choi, Yun-Jaie;Rowlands, J. Craig;Dahmen, Uta;Damm, Georg;Dirsch, Olaf;Teresa Donato, Maria;Dong, Jian;Dooley, Steven;Drasdo, Dirk;Eakins, Rowena;Ferreira, Karine Sa;Fonsato, Valentina;Fraczek, Joanna;Gebhardt, Rolf;Gibson, Andrew;Glanemann, Matthias;Goldring, Chris E. P.;Jose Gomez-Lechon, Maria;Groothuis, Geny M. M.;Gustavsson, Lena;Guyot, Christelle;Hallifax, David;Hammad, Seddik;Hayward, Adam;Haeussinger, Dieter;Hellerbrand, Claus;Hewitt, Philip;Hoehme, Stefan;Holzhuetter, Hermann-Georg;Houston, J. Brian;Hrach, Jens;Ito, Kiyomi;Jaeschke, Hartmut;Keitel, Verena;Kelm, Jens M.;Park, B. Kevin;Kordes, Claus;Kullak-Ublick, Gerd A.;LeCluyse, Edward L.;Lu, Peng;Luebke-Wheeler, Jennifer;Lutz, Anna;Maltman, Daniel J.;Matz-Soja, Madlen;McMullen, Patrick;Merfort, Irmgard;Messner, Simon;Meyer, Christoph;Mwinyi, Jessica;Naisbitt, Dean J.;Nussler, Andreas K.;Olinga, Peter;Pampaloni, Francesco;Pi, Jingbo;Pluta, Linda;Przyborski, Stefan A.;Ramachandran, Anup;Rogiers, Vera;Rowe, Cliff;Schelcher, Celine;Schmich, Kathrin;Schwarz, Michael;Singh, Bijay;Stelzer, Ernst H. K.;Stieger, Bruno;Stoeber, Regina;Sugiyama, Yuichi;Tetta, Ciro;Thasler, Wolfgang E.;Vanhaecke, Tamara;Vinken, Mathieu;Weiss, Thomas S.;Widera, Agata;Woods, Courtney G.;Xu, Jinghai James;Yarborough, Kathy M.;Hengstler, Jan G.
通讯作者：
Hengstler, Jan G.
影响因子：
6.1
作者：
Goral, Vasiliy N.;Hsieh, Yi-Cheng;Faris, Ronald A.
通讯作者：
Faris, Ronald A.
影响因子：
6.1
作者：
Agarwal A;Goss JA;Cho A;McCain ML;Parker KK
通讯作者：
Parker KK
DOI：
10.1039/c3ib40149a
发表时间：
2013-10
期刊：
Integrative biology : quantitative biosciences from nano to macro
影响因子：
--
作者：
Chen MB;Whisler JA;Jeon JS;Kamm RD
通讯作者：
Kamm RD
影响因子：
2.7
作者：
Cho CH;Park J;Tilles AW;Berthiaume F;Toner M;Yarmush ML
通讯作者：
Yarmush ML