Prefrontal cortical regulation of fear learning.

Prefrontal cortical regulation of fear learning.
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DOI:
10.1016/j.tins.2014.05.004
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发表时间:
2014-08
影响因子:
15.9
通讯作者:
Helmstetter FJ
Helmstetter FJ
中科院分区:
医学1区
文献类型:
--
作者:
Gilmartin MR;Balderston NL;Helmstetter FJ

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The prefrontal cortex regulates the expression of fear based on previously learned information. Recently, this brain area has emerged as critical in the initial formation of fear memories, providing new avenues to study the neurobiology underlying aberrant learning in anxiety disorders. Here we review the circumstances under which prefrontal cortex is recruited in the formation of memory, highlighting relevant work in both laboratory animals and human subjects. We propose that prefrontal cortex facilitates fear memory through integration of sensory and emotional signals and through coordination of memory storage in an amygdala-based network.
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