Copeptin and Nesfatin-1 Are Interrelated Biomarkers with Roles in the Pathogenesis of Insulin Resistance in Chinese Children with Obesity
Copeptin and Nesfatin-1 Are Interrelated Biomarkers with Roles in the Pathogenesis of Insulin Resistance in Chinese Children with Obesity
复制标题
和肽素和 Nesfatin-1 是相互关联的生物标志物，在中国肥胖儿童胰岛素抵抗的发病机制中发挥作用
DOI：
10.1159/000508883
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发表时间：
2020-10
影响因子：
3.9
通讯作者：
Xiao Yanfeng
中科院分区：
文献类型：
--
作者：
Yin Chunyan;Liu Weihua;Xu Erdi;Zhang Meizhen;Lv Weicheng;Lu Qi;Xiao Yanfeng
背景资料：和肽素和nesfatin-1是近年来发现的在成人肥胖相关胰岛素抵抗发病机制中发挥作用的新肽。然而，它们之间的关系尚未阐明，它们在肥胖儿童中的循环水平尚未得到充分研究。因此，本研究旨在调查中国肥胖儿童中它们的水平是否发生变化，以及确定这两种肽彼此之间、与胰岛素抵抗以及与其他生化参数的相关性。方法：156名儿童，其中肥胖儿童101名，非肥胖儿童55名。收集所有受试者的人体测量学参数和临床数据，并使用ELISA法测定循环肿瘤坏死因子-α、脂联素、瘦素、和肽素和nesfatin-1水平。结果如下：与对照组相比，肥胖儿童和胰岛素抵抗儿童的血清和肽素和nesfatin-1水平显著升高。此外，通过Pearson相关和偏相关发现nesfatin-1和和肽素水平彼此显著正相关。在使用nesfatin-1或和肽素作为依赖参数的多元回归分析中，观察到nesfatin-1和和肽素之间的显著相关性，并且检测到它们各自与胰岛素抵抗的稳态模型评估（HOMA-IR）之间的关联。结论：这些新的发现揭示了这两种分子在肥胖相关的胰岛素抵抗中可能的相互作用。
Background: Copeptin and nesfatin-1 have recently been identified as novel peptides that play a role in the pathogenesis of obesity-related insulin resistance in adults. However, the relationship between them has not yet been elucidated, and their circulating levels in children with obesity have not been adequately studied. Therefore, the current study aimed to investigate whether their levels are altered in Chinese children with obesity, as well as to determine the correlation of these 2 peptides with each other, with insulin resistance, and with other biochemical parameters. Methods: A total of 156 children were enrolled in this study, including 101 children with obesity and 55 lean controls. Anthropometric parameters and clinical data of all subjects were collected, and circulating tumor necrosis factor-α, adiponectin, leptin, copeptin, and nesfatin-1 levels were measured using ELISA. Results: Serum copeptin and nesfatin-1 levels were significantly elevated in children with obesity and children with insulin resistance compared to control subjects. In addition, nesfatin-1 and copeptin levels were found to be significantly positively correlated with one another by Pearson’s correlation and partial correlation. In multiple regression analysis using nesfatin-1 or copeptin as the dependent parameter, a significant correlation was observed between nesfatin-1 and copeptin, and associations between each of them with homeostasis model assessment of insulin resistance (HOMA-IR) were detected. Conclusion: These novel findings shed light on the possible interplay role of these 2 molecules in obesity-related insulin resistance.
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影响因子：
4
作者：
Karbek B;Ozbek M;Karakose M;Topaloglu O;Bozkurt NC;Cakır E;Aslan MS;Delibasi T
通讯作者：
Delibasi T
影响因子：
5.8
作者：
Levy-Marchal, Claire;Arslanian, Silva;Chiarelli, Francesco
通讯作者：
Chiarelli, Francesco
影响因子：
3
作者：
Tenderenda-Banasiuk, Edyta;Wasilewska, Anna;Filonowicz, Renata;Jakubowska, Urszula;Waszkiewicz-Stojda, Marlena
通讯作者：
Waszkiewicz-Stojda, Marlena
影响因子：
3.2
作者：
J. Rothermel;A. Kulle;P. Holterhus;Christina Toschke;Nina Lass;T. Reinehr
通讯作者：
J. Rothermel;A. Kulle;P. Holterhus;Christina Toschke;Nina Lass;T. Reinehr
影响因子：
3.8
作者：
de Dios, Olaya;Herrero, Leticia;Garces, Carmen
通讯作者：
Garces, Carmen