New cycloartane glycosides from the rhizomes of Cyperus rotundus and their antidepressant activity

New cycloartane glycosides from the rhizomes of Cyperus rotundus and their antidepressant activity
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香附根茎中新的环阿麻苷及其抗抑郁活性

DOI:
10.1080/10286020.2016.1142976
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发表时间:
2016-03
影响因子:
1.7
通讯作者:
Wen-qing Yin
Wen-qing Yin
中科院分区:
医学4区
文献类型:
--
作者:
Zhong-liu Zhou;San-qing Lin;Wen-qing Yin

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摘要从香附根茎中分离得到两个新的环丙烷苷,分别为环丙烷苷A(1)和环丙烷苷B(2)。通过红外光谱、质谱分析、核磁共振光谱分析和化学降解确定了它们的化学结构。对两个化合物的潜在抗抑郁活性进行了评价。在绝望小鼠模型中,化合物1和2显示出显著的抗抑郁活性。
Abstract Two new cycloartane glycosides, cyprotusides A (1) and B (2), were isolated from the rhizomes of Cyperus rotundus. Their chemical structures were elucidated on the basis of IR, MS, NMR spectroscopic analyses coupled with chemical degradation. The potential antidepressant activity of the two compounds was evaluated. In the despair mice models, compounds 1 and 2 showed significant antidepressant activity.
DOI: --
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