The CannTeen study: verbal episodic memory, spatial working memory, and response inhibition in adolescent and adult cannabis users and age-matched controls.
The CannTeen study: verbal episodic memory, spatial working memory, and response inhibition in adolescent and adult cannabis users and age-matched controls.
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DOI：
10.1007/s00213-022-06143-3
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发表时间：
2022-05
影响因子：
3.4
通讯作者：
Curran, H., V
中科院分区：
文献类型：
--
作者：
Lawn, W.;Fernandez-Vinson, N.;Mokrysz, C.;Hogg, G.;Lees, R.;Trinci, K.;Petrilli, K.;Borissova, A.;Ofori, S.;Waters, S.;Michor, P.;Wall, M. B.;Freeman, T. P.;Curran, H., V
关键词：
临床前和人类研究表明，青少年大麻使用可能与成人大麻使用相比更差的认知结果有关。我们调查了青少年和成年大麻使用者和对照者的慢性大麻使用与认知功能之间的关联。我们假设用户状态与认知功能呈负相关，并且这种关系在青少年中比成年人更强。作为“CannTeen”项目的一部分，这项横断面研究评估了青少年大麻使用者（n = 76; 16 - 17岁），青少年对照组（n = 63），成年大麻使用者（n = 71; 26 - 29岁）和成年对照组（n = 64）的认知表现。使用者每周使用大麻1 - 7天。青少年和成年大麻使用者在大麻使用频率（每周4天）和自上次使用以来的时间（2.5天）上进行了匹配。言语情景记忆（VEM）进行了评估，使用散文回忆任务，空间工作记忆（SWM）进行了评估，使用空间n-back任务，并与停止信号任务的反应抑制进行了评估。主要结果变量分别为：延迟回忆、3-back辨别力和停止信号反应时间。使用者的VEM比对照组更差（F（1，268）= 7.423，p = 0.007）。用户组之间的SWM或反应抑制没有显着差异。贝叶斯分析支持了显著差异。年龄组和用户组之间没有显着的相互作用，发现VEM，SWM，或反应抑制。与以前的研究一致，长期使用大麻与VEM较差之间存在关联，但长期使用大麻与SWM或反应抑制无关。我们没有发现青少年对大麻相关认知障碍的易感性增加的证据。在线版本包含补充材料，可通过10.1007/s00213 - 022 - 06143 - 3获得。
Preclinical and human studies suggest that adolescent cannabis use may be associated with worse cognitive outcomes than adult cannabis use. We investigated the associations between chronic cannabis use and cognitive function in adolescent and adult cannabis users and controls. We hypothesised user-status would be negatively associated with cognitive function and this relationship would be stronger in adolescents than adults. As part of the ‘CannTeen’ project, this cross-sectional study assessed cognitive performance in adolescent cannabis users (n = 76; 16–17-year-olds), adolescent controls (n = 63), adult cannabis users (n = 71; 26–29-year-olds) and adult controls (n = 64). Users used cannabis 1–7 days/week. Adolescent and adult cannabis users were matched on cannabis use frequency (4 days/week) and time since last use (2.5 days). Verbal episodic memory (VEM) was assessed using the prose recall task, spatial working memory (SWM) was assessed using the spatial n-back task, and response inhibition was assessed with the stop-signal task. Primary outcome variables were: delayed recall, 3-back discriminability, and stop signal reaction time, respectively. Users had worse VEM than controls (F(1,268) = 7.423, p = 0.007). There were no significant differences between user-groups on SWM or response inhibition. Null differences were supported by Bayesian analyses. No significant interactions between age-group and user-group were found for VEM, SWM, or response inhibition. Consistent with previous research, there was an association between chronic cannabis use and poorer VEM, but chronic cannabis use was not associated with SWM or response inhibition. We did not find evidence for heightened adolescent vulnerability to cannabis-related cognitive impairment. The online version contains supplementary material available at 10.1007/s00213-022-06143-3.
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DOI：
10.1080/13803395.2017.1385729
发表时间：
2018-08
影响因子：
2.2
作者：
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影响因子：
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DOI：
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发表时间：
2012
影响因子：
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