Novel betacoronavirus in dromedaries of the Middle East, 2013.

Novel betacoronavirus in dromedaries of the Middle East, 2013.
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2013年中东杂乱无章的小说中,贝塔科罗纳病毒。

DOI:
10.3201/eid2004.131769
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发表时间:
2014-04
影响因子:
11.8
通讯作者:
Yuen KY
Yuen KY
中科院分区:
医学2区
文献类型:
--
作者:
Woo PC;Lau SK;Wernery U;Wong EY;Tsang AK;Johnson B;Yip CC;Lau CC;Sivakumar S;Cai JP;Fan RY;Chan KH;Mareena R;Yuen KY

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2013年,在阿拉伯联合酋长国迪拜的单峰骆驼粪便样本中发现了一种新型β冠状病毒。在检测的59份单峰骆驼血清样本中,52%检测到针对该病毒重组核衣壳蛋白的抗体,我们将其命名为单峰骆驼冠状病毒(DcCoV)UAE-HKU 23。在对3个完整的DcCoV UAE-HKU 23基因组的分析中,我们将该病毒鉴定为A1谱系的β冠状病毒。DcCoV UAE-HKU 23基因组具有G+C含量;密码子第三位一般偏好G/C;刺突蛋白的切割位点;以及与其他β冠状病毒A1成员相似长度的膜蛋白,DcCoV UAE-HKU 23与其他β冠状病毒A1成员在遗传学上密切相关。沿着这种冠状病毒,至少有8个其他科的病毒被发现感染骆驼。由于骆驼与人类关系密切,因此应进行持续监测,以了解病毒在骆驼中出现和传播给人类的可能性。
In 2013, a novel betacoronavirus was identified in fecal samples from dromedaries in Dubai, United Arab Emirates. Antibodies against the recombinant nucleocapsid protein of the virus, which we named dromedary camel coronavirus (DcCoV) UAE-HKU23, were detected in 52% of 59 dromedary serum samples tested. In an analysis of 3 complete DcCoV UAE-HKU23 genomes, we identified the virus as a betacoronavirus in lineage A1. The DcCoV UAE-HKU23 genome has G+C contents; a general preference for G/C in the third position of codons; a cleavage site for spike protein; and a membrane protein of similar length to that of other betacoronavirus A1 members, to which DcCoV UAE-HKU23 is phylogenetically closely related. Along with this coronavirus, viruses of at least 8 other families have been found to infect camels. Because camels have a close association with humans, continuous surveillance should be conducted to understand the potential for virus emergence in camels and for virus transmission to humans.
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影响因子: 5.4
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DOI: 10.1016/s1473-3099(13)70164-6
发表时间: 2013-10
期刊: The Lancet. Infectious diseases
影响因子: --
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