The Effects of Fatty Acids on Inflammatory Bowel Disease: A Two-Sample Mendelian Randomization Study.
The Effects of Fatty Acids on Inflammatory Bowel Disease: A Two-Sample Mendelian Randomization Study.
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脂肪酸对炎症性肠病的影响：一项双样本孟德尔随机研究
DOI：
10.3390/nu14142883
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发表时间：
2022-07-14
期刊：
影响因子：
5.9
通讯作者：
Bai, Yang
中科院分区：
文献类型：
--
作者：
He, Jian;Luo, Xiaobei;Xin, Hongjie;Lai, Qianwei;Zhou, Yuanping;Bai, Yang
炎症性肠病（IBD）是一种严重的胃肠道复发性炎症。脂肪酸 (FA) 与 IBD 之间的关联存在争议，目前尚不清楚它们之间是否存在因果关系。孟德尔随机化 (MR) 分析是对来自同一国家的省/州的隶属关系进行分析，以澄清因果关系。从六项全基因组关联研究中选择了合格的单核苷酸多态性作为工具变量，涉及英国生物银行的 114,999 名个体。有关 IBD（包括克罗恩病 (CD) 和溃疡性结肠炎 (UC)）的汇总数据来自国际炎症性肠病遗传学联盟，涉及 20,883 人和 27,432 名个体。采用主要逆方差加权（IVW）方法以及其他补充分析方法来评估不同FA与IBD之间的因果关系。采用异质性和多效性检验以及留一分析来验证结果的稳定性。研究发现 Omega-3 FA 对 UC 而不是 CD 具有因果作用。 Omega-3 FA 基因水平每增加一个标准差，通过 IVW 方法 (p = 1.766 × 10−4) 发现溃疡性结肠炎的风险降低 39.9%，通过 MR Egger (p = 1.11 × 10−2) 降低 57.8%，通过加权中值估计量 (p = 7.706 ×) 降低 51.5% 10−4)，最大似然估计 (p = 3.262 × 10−4) 提高了 39%，惩罚加权中值估计量提高了 54.5% (p = 1.628 × 10−4)。未发现其他 FA（包括总 FA、饱和 FA、多不饱和 FA、单不饱和 FA 和 omega-6 FA）与 IBD 之间的因果关系。多效性检验和留一分析都证明了这些MR分析的有效性和可靠性。 Omega-3 FA 对 UC 具有保护作用，为研究 FA 与 IBD 之间的关联提供了新的视角。
Inflammatory Bowel Disease (IBD) is a severe relapsing inflammation of the gastrointestinal tract. The association between fatty acids (FAs) and IBD is controversial and it remains unclear whether there is a causal relationship between them. Mendelian randomization (MR) analysis was province/state for affiliations from the same country performed to clarify the causality. Eligible single nucleotide polymorphisms were selected as instrumental variables from six Genome-wide association studies, involving 114,999 individuals in UK Biobank. The summary-level data on IBD, including Crohn’s disease (CD) and ulcerative colitis (UC), were obtained from the International Inflammatory Bowel Disease Genetics Consortium with 20,883 and 27,432 individuals involved. The primary inverse variance weighted (IVW) method as well as other supplementary analysis ones were adopted to evaluate the causal relationship between diverse FAs and IBD. The tests for heterogeneity and pleiotropy, and Leave-one-out analysis were adopted to verify the stability of the results. Omega-3 FA was found to have a causal effect on UC instead of CD. For each Standard Deviation increase in Omega-3 FA genetic levels, the risk of ulcerative colitis was found to be reduced by 39.9% by the IVW method (p = 1.766 × 10−4), by 57.8% by the MR Egger (p = 1.11 × 10−2), by 51.5% by the Weighted median estimator (p = 7.706 × 10−4), by 39% by the Maximum likelihood estimation (p = 3.262 × 10−4), and by 54.5% by the penalized weighted median estimator (p = 1.628 × 10−4). No causal relationship was found between other FAs (including total FA, saturated FA, polyunsaturated FA, monounsaturated FA and omega-6 FA) and IBD. The pleiotropic test and Leave-one-out analysis both proved the validity and reliability of these MR analyses. Omega-3 FA was observed to have a protective effect against UC, providing a new perspective on the investigation of the associations between FAs and IBD.
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影响因子：
64.8
作者：
Bycroft C;Freeman C;Petkova D;Band G;Elliott LT;Sharp K;Motyer A;Vukcevic D;Delaneau O;O'Connell J;Cortes A;Welsh S;Young A;Effingham M;McVean G;Leslie S;Allen N;Donnelly P;Marchini J
通讯作者：
Marchini J
影响因子：
2.1
作者：
Bowden J;Davey Smith G;Haycock PC;Burgess S
通讯作者：
Burgess S
影响因子：
29.4
作者：
Costea, Irina;Mack, David R.;Amre, Devendra K.
通讯作者：
Amre, Devendra K.
溃疡性结肠炎。
DOI：
10.1016/s0140-6736(16)32126-2
发表时间：
2017-04-29
期刊：
Lancet (London, England)
影响因子：
--
作者：
Ungaro R;Mehandru S;Allen PB;Peyrin-Biroulet L;Colombel JF
通讯作者：
Colombel JF
DOI：
10.1136/bmj-2021-066452
发表时间：
2022-01-26
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Hahn J;Cook NR;Alexander EK;Friedman S;Walter J;Bubes V;Kotler G;Lee IM;Manson JE;Costenbader KH
通讯作者：
Costenbader KH