Rodent models of nicotine reward: what do they tell us about tobacco abuse in humans?
Rodent models of nicotine reward: what do they tell us about tobacco abuse in humans?
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DOI：
10.1016/j.pbb.2008.12.011
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发表时间：
2009-02
影响因子：
3.6
通讯作者：
Khroyan, Taline V.
中科院分区：
文献类型：
--
作者：
O'Dell, Laura E.;Khroyan, Taline V.
关键词：
烟草产品在人类中广泛滥用，人们认为尼古丁是这些产品中产生成瘾的关键底物。基于这一假设，一些临床前研究利用动物模型来测量尼古丁成瘾的各个方面。这项工作的大部分重点是尼古丁的行为测量以及其他变量如何影响这些影响。在这里，我们讨论最常用的动物模型，包括啮齿类动物的自我给药（SA）、位置调节（PC）和颅内自我刺激（ICSS）范例。回顾了这些模型的优点、局限性和程序变量，然后讨论了如何使用动物模型来研究年龄、性别、压力以及尼古丁以外的烟草产品的影响等因素。我们根据这些因素对人类烟草滥用的影响进行讨论。啮齿动物模型在面部、预测和结构有效性的背景下进行评估，我们建议纳入年龄、性别、压力和除尼古丁之外的其他烟草成分等因素，可以通过更接近地模仿人类烟草滥用来提高这些动物模型的实用性。
Tobacco products are widely abused in humans, and it is assumed that nicotine is the key substrate in these products that produces addiction. Based on this assumption, several pre-clinical studies have utilized animal models to measure various aspects of nicotine addiction. Most of this work has focused on behavioral measures of nicotine and how other variables contribute to these effects. Here we discuss the most commonly used animal models including, self-administration (SA), place conditioning (PC), and the intracranial self-stimulation (ICSS) paradigms in rodents. The strengths, limitations and procedural variables of these models are reviewed, followed by a discussion of how the animal models have been used to study factors such as age, sex, stress, and the effects of tobacco products other than nicotine. These factors are discussed in light of their influences on human tobacco abuse. The rodent models are evaluated in the context of face, predictive, and construct validity, and we propose that inclusion of factors such as age, sex, stress and other constituents of tobacco aside from nicotine can increase the utility of these animal models by more closely mimicking human tobacco abuse.
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影响因子：
3.4
作者：
Fowler, JS;Logan, J;Volkow, ND
通讯作者：
Volkow, ND
影响因子：
3.4
作者：
Cousins, MS;Stamat, HM;de Wit, H
通讯作者：
de Wit, H
DOI：
10.1124/jpet.107.132977
发表时间：
2008-04-01
影响因子：
3.5
作者：
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通讯作者：
Damaj, M. I.
影响因子：
3.4
作者：
CORRIGALL, WA;COEN, KM
通讯作者：
COEN, KM
影响因子：
7.6
作者：
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通讯作者：
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