Evidence for dissociable motor skills in Huntington’s disease patients
Evidence for dissociable motor skills in Huntington’s disease patients
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亨廷顿病患者分离运动技能的证据
DOI：
10.3758/bf03327132
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
W. Koroshetz
中科院分区：
文献类型：
--
作者：
D. Willingham;W. Koroshetz
有人提出纹状体对于获得新的运动技能至关重要。先前的实验表明，纹状体功能障碍的患者在获得新的运动技能方面受到损害，但任务总是使用以重复的、可预测的模式运动的刺激。四个实验表明，亨廷顿氏病（HD）患者在学习这些技能方面受损，但可以以正常的速度学习需要学习新的感知-运动映射的技能。血液透析患者在学习重复的运动序列的按键任务受损。当重复序列被删除，刺激反应映射空间不兼容，HD患者表现出正常的学习。HD患者在用电脑鼠标做出反应时学会了迷宫任务，但在需要按键反应的变化中受损。对照组受试者对鼠标版本的重复动作序列不敏感，但他们的部分知识是基于按键版本的序列。运动技能成分的神经基础进行了讨论。
It has been proposed that the striatum is critical for acquiring new motor skills. Previous experiments have shown that patients with striatal dysfunction are impaired in acquiring new motor skills, but the tasks have always used stimuli that move in a repeating, predictable pattern. Four experiments showed that Huntington’s disease (HD) patients are impaired in learning such skills, but can learn at a normal rate skills that require the learning of a new perceptual-motor mapping. HD patients were impaired in learning a repeating motor sequence in a keypressing task. When the repeating sequence was removed and the stimulus-response mapping was made spatially incompatible, HD patients showed normal learning. HD patients learned a maze task when responding with a computer mouse but were impaired on a variation that required keypress responses. Control subjects showed no sensitivity to the repetitive sequence of movements in the mouse version, but part of their knowledge was sequence based in the keypress version. The neural basis of motor skill components is discussed.
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健忘症中保留的学习和记忆：完整的适应水平效应和立体深度学习。
影响因子：
1.9
作者：
Benzing,WC;Squire,LR
通讯作者：
Squire,LR
影响因子：
56.9
作者：
COHEN, NJ;SQUIRE, LR
通讯作者：
SQUIRE, LR
影响因子：
1.9
作者：
Heindel,WC;Butters,N;Salmon,DP
通讯作者：
Salmon,DP
DOI：
10.1002/9780470513545.ch3
发表时间：
1987
期刊：
Ciba Foundation symposium
影响因子：
--
作者：
Jones,EG
通讯作者：
Jones,EG