Noncontact Speckle Contrast Diffuse Correlation Tomography of Blood Flow Distributions in Burn Wounds: A Preliminary Study.
Noncontact Speckle Contrast Diffuse Correlation Tomography of Blood Flow Distributions in Burn Wounds: A Preliminary Study.
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烧伤创面血流分布的非接触散斑对比漫射相关断层扫描：初步研究。
DOI：
10.1093/milmed/usz233
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发表时间：
2020
影响因子：
1.2
通讯作者：
Yu,Guoqiang
中科院分区：
文献类型：
--
作者：
Zhao,Mingjun;Mazdeyasna,Siavash;Huang,Chong;Agochukwu-Nwubah,Nneamaka;Bonaroti,Alisha;Wong,Lesley;Yu,Guoqiang
简介：组织损伤通常与异常血流（BF）有关。评估BF在受伤组织中的分布的能力使得能够客观地评估干预措施，并具有改善战场上这些损伤的急性管理的潜力。材料与方法：我们已经开发了一种新的散斑衬度扩散相关断层成像（scDCT）系统的非接触三维成像的组织BF分布。在scDCT中，使用振镜将近红外点光远程投射到不同的光源位置，并使用电子倍增电荷耦合器件检测边界漫散斑对比度。然后将归一化的边界数据插入到修改后的近红外荧光和光谱断层扫描程序中，用于BF分布的3D重建。本文报告了scDCT在烧伤创面BF分布非接触式3D成像中的首次应用。结果：与周围正常组织相比，在烧伤区域/体积中观察到显著较低的BF值。结论：独特的非接触式3D成像能力使scDCT适用于烧伤/伤口的术中评估，没有感染风险，也不会干扰术野的无菌性。便携式scDCT设备具有被外科医生用于作战外科医院以改善战场烧伤的急性管理的潜力。
Introduction: Tissue injuries are often associated with abnormal blood flow (BF). The ability to assess BF distributions in injured tissues enables objective evaluation of interventions and holds the potential to improve the acute management of these injuries on battlefield. Materials and Methods: We have developed a novel speckle contrast diffuse correlation tomography (scDCT) system for noncontact 3D imaging of tissue BF distributions. In scDCT, a galvo mirror was used to remotely project near-infrared point light to different source positions and an electron multiplying charge-coupled-device was used to detect boundary diffuse speckle contrasts. The normalized boundary data were then inserted into a modified Near-Infrared Fluorescence and Spectral Tomography program for 3D reconstructions of BF distributions. This article reports the first application of scDCT for noncontact 3D imaging of BF distributions in burn wounds. Results: Significant lower BF values were observed in the burned areas/volumes compared to surrounding normal tissues. Conclusions: The unique noncontact 3D imaging capability makes the scDCT applicable for intraoperative assessment of burns/wounds, without risk of infection and without interfering with sterility of the surgical field. The portable scDCT device holds the potential to be used by surgeons in combat surgical hospitals to improve the acute management of battlefield burn injuries.
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