Working memory in survivors of childhood acute lymphocytic leukemia: functional neuroimaging analyses.
Working memory in survivors of childhood acute lymphocytic leukemia: functional neuroimaging analyses.
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DOI：
10.1002/pbc.22362
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发表时间：
2010-04
影响因子：
3.2
通讯作者：
Compas, Bruce E.
中科院分区：
文献类型：
--
作者：
Robinson, Kristen E.;Livesay, Katherine L.;Campbell, Laura K.;Scaduto, Mary;Cannistraci, Christopher J.;Anderson, Adam W.;Whitlock, James A.;Compas, Bruce E.
对儿童癌症治疗的生理和心理后期影响的研究发现，一些幸存者经历了严重的长期神经认知缺陷，特别是在记忆和执行功能方面。尽管基于认知评估的缺陷的迹象，使用神经成像技术的神经认知缺陷的具体机制的识别尚未得到充分考虑。本研究采用功能性神经影像学技术，检查儿童急性淋巴细胞白血病（ALL）幸存者的工作记忆和执行功能缺陷，与年龄和性别匹配的健康对照组相比。有一种趋势是所有幸存者在工作记忆任务中的整体准确性表现更差。此外，幸存者在工作记忆（背外侧和腹外侧前额叶皮层）和错误监控（背侧和腹侧前扣带皮层）的潜在区域中显示出显着更大的激活。这些结果支持在必要的大脑区域的补偿性激活的理论，以完成儿童ALL幸存者的任务，类似于在多发性硬化症患者中观察到的。同时检查测试和脑成像，使行为观察与潜在的神经功能障碍的幸存者的特点，并可能有助于提供洞察机制，通过赤字出现。
Research on the physical and psychological late effects of treatment of childhood cancer has led to the identification of significant long-term neurocognitive deficits experienced by some survivors, particularly in the areas of memory and executive functioning. Despite indications of deficits based on cognitive assessment, the identification of specific mechanisms of neurocognitive deficits using neuroimaging techniques has yet to be adequately considered. This study used functional neuroimaging techniques to examine working memory and executive functioning deficits of survivors of childhood Acute Lymphocytic Leukemia (ALL), as compared to age and gender matched healthy controls. There was a trend for ALL survivors to perform more poorly on a working memory task in terms of overall accuracy. Additionally, survivors displayed significantly greater activation in areas underlying working memory (dorsolateral and ventrolateral prefrontal cortex) and error monitoring (dorsal and ventral anterior cingulate cortex). These results support the theory of compensatory activation in necessary brain regions in order to complete tasks in pediatric ALL survivors, similar to that observed in multiple sclerosis patients. Concurrent examination of testing and brain imaging enables the connection of behavioral observations with underlying neurological characteristics of deficits in survivors and may help provide insight into mechanisms through which deficits appear.
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影响因子：
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