Multichannel detrended fluctuation analysis reveals synchronized patterns of spontaneous spinal activity in anesthetized cats.
Multichannel detrended fluctuation analysis reveals synchronized patterns of spontaneous spinal activity in anesthetized cats.
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DOI：
10.1371/journal.pone.0026449
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Rudomín P
中科院分区：
文献类型：
--
作者：
Rodríguez EE;Hernández-Lemus E;Itzá-Ortiz BA;Jiménez I;Rudomín P
分析相对较大的神经元集合的相互作用和同步是理解神经系统复杂功能的基础。已知神经系综的时间同步参与特定运动、感觉或认知过程的产生。此外，脊髓自发活动的节段间一致性可能表明不同对腰椎节段之间存在突触神经通路。在这项研究中，我们提出了一个多通道版本的去趋势波动分析方法（mDFA）分析的相关动力学的自发性脊髓活动（SSA）的时间序列分析。这种方法与经典的去趋势波动分析（DFA）一起被用来找出记录在麻醉猫脊髓的一个或几个节段中的SSA是随机发生的还是有组织的方式。我们的研究结果是一致的一个非随机组织的神经元参与的自发脊髓背电位（CDP）的产生记录从一个腰椎节段（DFA-平均值= 1.040.09）或同时从几个腰椎节段（mDFA-平均值= 1.010.06），其中= 0.5表示随机性，而0.5表示长期相关性。 为了测试mDFA方法的灵敏度，我们还检查了旨在部分中断相邻腰骶段之间连接的小脊柱病变的影响。我们发现，当在L5和L 6节段之间进行包括左背象限的病变时，从脊髓两侧的L5和L 6节段记录的CDP之间的同步性和相关性降低（与初始条件mDFA-= 1.186相比，mDFA-=0.992）。 在类似的额外右侧脊柱病变后，同步性和相关性进一步降低（mDFA-= 0.924）。 与经典方法（例如定义两组数据之间的关系的相关性和相干性量化）相比，mDFA方法正确地揭示了脊髓几个节段中多组神经元的同步。这种方法被设想为一个有用的工具，以表征结构的高阶合奏的脊髓或周围神经损伤后的脊髓背自发电位。
The analysis of the interaction and synchronization of relatively large ensembles of neurons is fundamental for the understanding of complex functions of the nervous system. It is known that the temporal synchronization of neural ensembles is involved in the generation of specific motor, sensory or cognitive processes. Also, the intersegmental coherence of spinal spontaneous activity may indicate the existence of synaptic neural pathways between different pairs of lumbar segments. In this study we present a multichannel version of the detrended fluctuation analysis method (mDFA) to analyze the correlation dynamics of spontaneous spinal activity (SSA) from time series analysis. This method together with the classical detrended fluctuation analysis (DFA) were used to find out whether the SSA recorded in one or several segments in the spinal cord of the anesthetized cat occurs either in a random or in an organized manner. Our results are consistent with a non-random organization of the sets of neurons involved in the generation of spontaneous cord dorsum potentials (CDPs) recorded either from one lumbar segment (DFA- mean = 1.040.09) or simultaneously from several lumbar segments (mDFA- mean = 1.010.06), where = 0.5 indicates randomness while 0.5 indicates long-term correlations. To test the sensitivity of the mDFA method we also examined the effects of small spinal lesions aimed to partially interrupt connectivity between neighboring lumbosacral segments. We found that the synchronization and correlation between the CDPs recorded from the L5 and L6 segments in both sides of the spinal cord were reduced when a lesion comprising the left dorsal quadrant was performed between the segments L5 and L6 (mDFA- = 0.992 as compared to initial conditions mDFA- = 1.186). The synchronization and correlation were reduced even further after a similar additional right spinal lesion (mDFA- = 0.924). In contrast to the classical methods, such as correlation and coherence quantification that define a relation between two sets of data, the mDFA method properly reveals the synchronization of multiple groups of neurons in several segments of the spinal cord. This method is envisaged as a useful tool to characterize the structure of higher order ensembles of cord dorsum spontaneous potentials after spinal cord or peripheral nerve lesions.
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DOI：
10.3109/13813454109145564
发表时间：
1941-01-01
期刊：
ARCH INTERNAT PHYSIOL
影响因子：
--
作者：
BREMER, F.
通讯作者：
BREMER, F.
影响因子：
5.5
作者：
Manjarrez, E;Rojas-Piloni, JG;Rudomin, P
通讯作者：
Rudomin, P
影响因子：
2.9
作者：
KASPRZAK, H;GASTEIGER, EL
通讯作者：
GASTEIGER, EL
影响因子：
2.5
作者：
García, CA;Chávez, D;Rudomin, P
通讯作者：
Rudomin, P
影响因子：
37.8
作者：
Goldberger, AL;Amaral, LAN;Stanley, HE
通讯作者：
Stanley, HE