Neuroimaging in Psychopathy
Neuroimaging in Psychopathy
复制标题
精神病的神经影像学
DOI：
10.1080/j.1440-1614.2005.01679.x
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发表时间：
2005
影响因子：
4.6
通讯作者：
M. Mcarthur
中科院分区：
文献类型：
--
作者：
S. Pridmore;Amber Chambers;M. Mcarthur
目的：精神病的生物学基础仍有待充分阐明。有证据表明遗传因素和血清素系统功能障碍。本文的目的是回顾过去十年神经影像学对我们理解精神病的贡献。方法：使用 PubMed 和“精神病患者”、“反社会型人格障碍”、“反社会型人格障碍”、“暴力”、“形象”和“影像”等词进行文献检索。此外，还仔细阅读了已确定论文的参考文献列表和最近的教科书，以获取其他来源。结果：选择并检查了 5 项结构性神经影像学研究和 15 项功能性神经影像学研究。结构研究报告称，前额叶灰质减少，海马后部体积减少，胼胝体白质增加，但到目前为止，这些还没有被复制。功能研究表明额叶和颞叶的灌注和代谢减少。据报道，功能异常主要发生在经典条件反射和反应抑制任务期间的额叶和颞叶结构，以及情感文字和图片的处理过程中。结论：功能性神经影像强烈提示精神病患者特定额叶和颞叶结构的功能障碍。然而，选择同质指标病例和适当的对照组存在困难。进一步的研究是必要的。反应取决于遗传禀赋、早期生活经历、社会文化背景以及任何刺激对个人的重要性。
Objective: The biological basis of psychopathy remains to be fully elucidated. Evidence suggests a genetic contribution and dysfunction of the serotonin system. The objective of this article is to review the contribution of the neuroimaging of the last decade to our understanding of psychopathy. Method: A literature search was conducted using PubMed and the words psychopath, antisocial personality disorder, dissocial personality disorder, violence, image and imaging. In addition, the reference lists of the identified papers, and recent textbooks, were perused for additional sources. Results: Five structural and 15 functional neuroimaging studies were selected and examined. Structural studies have reported decreased prefrontal grey matter, decreased posterior hippocampal volume and increased callosal white matter, but to this point, these have not been replicated. Functional studies suggest reduced perfusion and metabolism in the frontal and temporal lobes. Abnormalities of function have been reported, predominantly in frontal and temporal lobe structures during classical conditioning and response inhibition tasks, and in the processing of emotional words and pictures. Conclusion: Functional neuroimaging strongly suggests dysfunction of particular frontal and temporal lobe structures in psychopathy. However, there are difficulties in selecting homogeneous index cases and appropriate control groups. Further studies are necessary. Responses depend on genetic endowment, early life experience, the sociocultural context and the significance of any stimulus to the individual.
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影响因子：
--
作者：
R. Cadoret;W. Yates;E. Troughton;G. Woodworth;M. Stewart
通讯作者：
R. Cadoret;W. Yates;E. Troughton;G. Woodworth;M. Stewart
影响因子：
--
作者：
Raine, A;Lencz, T;Colletti, P
通讯作者：
Colletti, P
影响因子：
--
作者：
Raine, A;Lencz, T;Colletti, P
通讯作者：
Colletti, P
缺乏社会心理剥夺的杀人犯的前额葡萄糖缺乏。
DOI：
--
发表时间：
1998
期刊：
Neuropsychiatry, neuropsychology, and behavioral neurology
影响因子：
--
作者：
Raine,A;Phil,D;Stoddard,J;Bihrle,S;Buchsbaum,M
通讯作者：
Buchsbaum,M
反社会人格障碍、儿童犯罪和额叶脑功能：脑电图和神经心理学发现。
DOI：
10.1002/(sici)1097-4679(199611)52:6
发表时间：
1996
期刊：
Journal of clinical psychology.
影响因子：
--
作者：
Deckel,AW;Hesselbrock,V;Bauer,L
通讯作者：
Bauer,L