Clinicopathological and prognostic impact of imaging of breast cancer angiogenesis and hypoxia using diffuse optical spectroscopy.
Clinicopathological and prognostic impact of imaging of breast cancer angiogenesis and hypoxia using diffuse optical spectroscopy.
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DOI：
10.1111/cas.12432
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发表时间：
2014-07
期刊：
影响因子：
5.7
通讯作者：
Saeki T
中科院分区：
文献类型：
--
作者：
Nakamiya N;Ueda S;Shigekawa T;Takeuchi H;Sano H;Hirokawa E;Shimada H;Suzuki H;Oda M;Osaki A;Saeki T
近红外漫射光谱学（DOS）成像可以通过与正常组织的高对比度无创测量肿瘤血红蛋白浓度，从而提供血管和氧合状态。我们评估了DOS成像在原发性乳腺癌中的临床应用价值。总共纳入了118名组织学上确诊为原发性恶性肿瘤的女性。所有参与者在治疗开始前都进行了时间分辨DOS测试。两名不了解临床资料的阅读者对DOS成像检测肿瘤进行视觉评价。比较肿瘤的相对总血红蛋白（rtHb）和氧饱和度（stO2）与临床病理指标，并计算10年预后。基于rtHb乳腺图检测肿瘤的敏感性为62.7%（74/118）。敏感性取决于T分期：T3为100% (7/7)，T2为78.9% (45/57)，T1为44.7% (17/38)，Tis为31.3%（5/16）。肿瘤表现出比正常乳腺组织更高的rtHb和更宽的stO2范围的独特特征，这取决于组织学类型。rtHb与肿瘤大小、淋巴血管浸润及组织学分级有显著相关性，stO2与年龄及肿瘤大小有显著相关性。rtHb和stO2与雌激素受体、孕激素受体或人表皮生长因子受体2等内在生物标志物无关；rtHb与10年无复发生存率和总生存率呈负相关，差异有统计学意义。漫射光谱学成像对乳腺癌早期检测的效用有限；尽管如此，研究结果表明，肿瘤血管生成和缺氧的程度可能与肿瘤的侵袭性和不良预后有关。
Near-infrared diffuse optical spectroscopy (DOS) imaging can non-invasively measure tumor hemoglobin concentration using high contrast to normal tissue, thus providing vascularity and oxygenation status. We assessed the clinical usefulness of DOS imaging in primary breast cancer. In all, 118 women with a histologically confirmed diagnosis of primary malignant tumor were enrolled. All participants underwent testing using time-resolved DOS before treatment initiation. Visual assessment of DOS imaging for detecting tumors was carried out by two readers blinded to the clinical data. Relative total hemoglobin (rtHb) and oxygen saturation (stO2) of the tumors was compared with clinicopathological variables and 10-year prognosis was calculated. Sensitivity for detecting a tumor based on the rtHb breast map was 62.7% (74/118). The sensitivity depended on T stage: 100% (7/7) for T3, 78.9% (45/57) for T2, 44.7% (17/38) for T1, and 31.3% (5/16) for Tis. Tumors showed unique features of higher rtHb with a wider range of stO2 than normal breast tissue, depending on histological type. There was a significant correlation of rtHb with tumor size, lymphatic vascular invasion, and histological grade, and of stO2 with age and tumor size. Neither rtHb nor stO2 correlated with intrinsic biomarkers such as estrogen receptor, progesterone receptor, or human epidermal growth factor receptor 2; rtHb inversely correlated with 10-year relapse-free survival and overall survival, with statistical significance. Diffuse optical spectroscopy imaging has limited utility for the early detection of breast cancer; nonetheless, the findings suggest that the degree of tumor angiogenesis and hypoxia may be associated with tumor aggressiveness and poor prognosis.
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影响因子：
3.5
作者：
Ardeshirpour Y;Huang M;Zhu Q
通讯作者：
Zhu Q
乳房原位（DCIS）周围的导管癌周围的血管密度和表型。
影响因子：
8.8
作者：
Teo, N B;Shoker, B S;Jarvis, C;Martin, L;Sloane, J P;Holcombe, C
通讯作者：
Holcombe, C
影响因子：
3.8
作者：
Tromberg, Bruce J.;Pogue, Brian W.;Cerussi, Albert E.
通讯作者：
Cerussi, Albert E.
影响因子：
3.8
作者：
Arnes, Jarle B.;Stefansson, Ingunn M.;Akslen, Lars A.
通讯作者：
Akslen, Lars A.
影响因子：
3.3
作者：
Adler, Esther H.;Sunkara, Jaya L.;Oktay, Maja H.
通讯作者：
Oktay, Maja H.